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Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing.

Publication ,  Journal Article
Ram, DR; Kroll, K; Reeves, RK
Published in: AIDS Res Hum Retroviruses
December 2020

Natural killer (NK) cells provide some of the earliest immune responses to infection, but when viruses manipulate or perturb the immune environment to alter NK cell function, this places the host at a disadvantage. Indeed, others and we observe that in the context of HIV/simian immunodeficiency virus (SIV) infection, although NK cells are not infected, they can become dysfunctional over time. Several studies have characterized protein and transcriptional profiles of NK cells during HIV/SIV infection, but none have examined whether the production of alternative transcripts and corresponding isoforms is modulated. This phenomenon occurs broadly in normal biology and in other disease states, and could provide a novel avenue of investigation that may yield better targets to restore or augment NK cell responses to HIV/SIV. Herein, we briefly summarize published and new data that may provide a perspective on how to target NK cell splice variants.

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Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

December 2020

Volume

36

Issue

12

Start / End Page

969 / 972

Location

United States

Related Subject Headings

  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Killer Cells, Natural
  • HIV Infections
  • Animals
  • Alternative Splicing
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Ram, D. R., Kroll, K., & Reeves, R. K. (2020). Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing. AIDS Res Hum Retroviruses, 36(12), 969–972. https://doi.org/10.1089/AID.2020.0116
Ram, Daniel R., Kyle Kroll, and R Keith Reeves. “Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing.AIDS Res Hum Retroviruses 36, no. 12 (December 2020): 969–72. https://doi.org/10.1089/AID.2020.0116.
Ram DR, Kroll K, Reeves RK. Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing. AIDS Res Hum Retroviruses. 2020 Dec;36(12):969–72.
Ram, Daniel R., et al. “Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing.AIDS Res Hum Retroviruses, vol. 36, no. 12, Dec. 2020, pp. 969–72. Pubmed, doi:10.1089/AID.2020.0116.
Ram DR, Kroll K, Reeves RK. Skipped Over: Tuning Natural Killer Cells Toward HIV Through Alternative Splicing. AIDS Res Hum Retroviruses. 2020 Dec;36(12):969–972.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

EISSN

1931-8405

Publication Date

December 2020

Volume

36

Issue

12

Start / End Page

969 / 972

Location

United States

Related Subject Headings

  • Virology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Killer Cells, Natural
  • HIV Infections
  • Animals
  • Alternative Splicing
  • 3202 Clinical sciences
  • 1103 Clinical Sciences