Scholars@Duke
Journal cover image

Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.

Publication ,  Journal Article
Mendiola Pla, M; Milano, CA; Chiang, Y; Bishawi, M; Kang, L; Lee, FH; Smith, MF; Gross, RT; Contreras, FJ; Glass, C; Bowles, DE; Fudim, M
Published in: J Cardiovasc Transl Res
June 2023
Published version (DOI) Link to item

The porcine intra-abdominal heterotopic heart transplantation model allows for the assessment of immunologic effects on cardiac transplantation without relying on the allograft to maintain hemodynamic support for the animal. Historically, allograft function and histology is monitored by physical exam, echocardiogram evaluation, percutaneous core biopsy, and open biopsy. We performed transvenous endomyocardial biopsies in three pigs that had undergone heterotopic heart implantation. We describe the procedure to be feasible and reproducible, and that histologic results from these biopsies correlated with those from corresponding tissue collected by surgical dissection at the time of allograft explantation. The ability to perform endomyocardial biopsies in the heterotopic heart transplantation model allows for serial non-invasive monitoring of allograft histology.

Duke Scholars

Dawn Elizabeth Bowles
Author Dawn Elizabeth Bowles Surgery, Surgical Sciences
Marat Fudim
Author Marat Fudim Medicine, Cardiology
Carmelo Alessio Milano
Author Carmelo Alessio Milano Surgery, Cardiovascular and Thoracic Surgery
Carolyn Glass
Author Carolyn Glass Pathology
Muath Bishawi
Author Muath Bishawi  

Published In

J Cardiovasc Transl Res

DOI

10.1007/s12265-022-10337-7

EISSN

1937-5395

Publication Date

June 2023

Volume

16

Issue

3

Start / End Page

748 / 750

Location

United States

Related Subject Headings

  • Tissue Donors
  • Swine
  • Myocardium
  • Humans
  • Heart Transplantation
  • Heart
  • Graft Rejection
  • Biopsy
  • Animals
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mendiola Pla, M., Milano, C. A., Chiang, Y., Bishawi, M., Kang, L., Lee, F. H., … Fudim, M. (2023). Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts. J Cardiovasc Transl Res, 16(3), 748–750. https://doi.org/10.1007/s12265-022-10337-7
Mendiola Pla, Michelle, Carmelo A. Milano, Yuting Chiang, Muath Bishawi, Lillian Kang, Franklin H. Lee, Matthew F. Smith, et al. “Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.” J Cardiovasc Transl Res 16, no. 3 (June 2023): 748–50. https://doi.org/10.1007/s12265-022-10337-7.
Mendiola Pla M, Milano CA, Chiang Y, Bishawi M, Kang L, Lee FH, et al. Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts. J Cardiovasc Transl Res. 2023 Jun;16(3):748–50.
Mendiola Pla, Michelle, et al. “Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts.” J Cardiovasc Transl Res, vol. 16, no. 3, June 2023, pp. 748–50. Pubmed, doi:10.1007/s12265-022-10337-7.
Mendiola Pla M, Milano CA, Chiang Y, Bishawi M, Kang L, Lee FH, Smith MF, Gross RT, Contreras FJ, Glass C, Bowles DE, Fudim M. Transvenous Endomyocardial Biopsy Technique for Intra-abdominal Heterotopic Cardiac Grafts. J Cardiovasc Transl Res. 2023 Jun;16(3):748–750.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

10.1007/s12265-022-10337-7

EISSN

1937-5395

Publication Date

June 2023

Volume

16

Issue

3

Start / End Page

748 / 750

Location

United States

Related Subject Headings

  • Tissue Donors
  • Swine
  • Myocardium
  • Humans
  • Heart Transplantation
  • Heart
  • Graft Rejection
  • Biopsy
  • Animals
  • 3201 Cardiovascular medicine and haematology