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Metabolism and Colorectal Cancer.

Publication ,  Journal Article
Sedlak, JC; Yilmaz, ÖH; Roper, J
Published in: Annu Rev Pathol
January 24, 2023

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient-poor environments. Intestinal stem cells (ISCs), the primary cell of origin for CRCs, must adapt their metabolism along the adenoma-carcinoma sequence to the unique features of their complex microenvironment that include interactions with intestinal epithelial cells, immune cells, stromal cells, commensal microbes, and dietary components. Emerging evidence implicates modifiable risk factors related to the environment, such as diet, as important in CRC pathogenesis. Here, we focus on describing the metabolism of ISCs, diets that influence CRC initiation, CRC genetics and metabolism, and the tumor microenvironment. The mechanistic links between environmental factors, metabolic adaptations, and the tumor microenvironment in enhancing or supporting CRC tumorigenesis are becoming better understood. Thus, greater knowledge of CRC metabolism holds promise for improved prevention and treatment.

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Published In

Annu Rev Pathol

DOI

EISSN

1553-4014

Publication Date

January 24, 2023

Volume

18

Start / End Page

467 / 492

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Pathology
  • Humans
  • Gastrointestinal Microbiome
  • Diet
  • Colorectal Neoplasms
  • Cell Transformation, Neoplastic
  • Carcinogenesis
  • 3202 Clinical sciences
 

Citation

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MLA
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Sedlak, J. C., Yilmaz, Ö. H., & Roper, J. (2023). Metabolism and Colorectal Cancer. Annu Rev Pathol, 18, 467–492. https://doi.org/10.1146/annurev-pathmechdis-031521-041113
Sedlak, Joseph C., Ömer H. Yilmaz, and Jatin Roper. “Metabolism and Colorectal Cancer.Annu Rev Pathol 18 (January 24, 2023): 467–92. https://doi.org/10.1146/annurev-pathmechdis-031521-041113.
Sedlak JC, Yilmaz ÖH, Roper J. Metabolism and Colorectal Cancer. Annu Rev Pathol. 2023 Jan 24;18:467–92.
Sedlak, Joseph C., et al. “Metabolism and Colorectal Cancer.Annu Rev Pathol, vol. 18, Jan. 2023, pp. 467–92. Pubmed, doi:10.1146/annurev-pathmechdis-031521-041113.
Sedlak JC, Yilmaz ÖH, Roper J. Metabolism and Colorectal Cancer. Annu Rev Pathol. 2023 Jan 24;18:467–492.

Published In

Annu Rev Pathol

DOI

EISSN

1553-4014

Publication Date

January 24, 2023

Volume

18

Start / End Page

467 / 492

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Pathology
  • Humans
  • Gastrointestinal Microbiome
  • Diet
  • Colorectal Neoplasms
  • Cell Transformation, Neoplastic
  • Carcinogenesis
  • 3202 Clinical sciences