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Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study.

Publication ,  Journal Article
Bodd, MH; Locke, SC; Wolf, SP; Antonia, S; Crawford, J; Hartman, J; Herring, KW; Ready, NE; Stinchcombe, TE; Troy, JD; Williams, C; Clarke, JM ...
Published in: Lung Cancer
January 2023

OBJECTIVES: There are limited real-world data about patient-reported outcomes with immunotherapies (IO) in metastatic non-small cell lung cancer (mNSCLC). We describe patient-reported distress and clinical outcomes with IO-based treatments or cytotoxic chemotherapies (Chemo). METHODS: We conducted a single-institution retrospective chart review of adults with mNSCLC treated at Duke from 03/2015 to 06/2020. At each visit, patients self-reported their distress level and sources of distress using the NCCN Distress Thermometer (DT) and its 39-item Problem List. We abstracted demographic, clinical, distress, and investigator assessed-clinical response data, then analyzed these using descriptive statistics and generalized estimating equations. RESULTS: Data from 152 patients were analyzed in four groups: Chemo alone, IO + Chemo, single agent IO, dual agent IO. Distress was worse before treatment start in all groups, and the odds of actionable distress (DT score > 4) decreased by 10 % per month. The most frequent sources of distress were physical symptoms (e.g., fatigue, pain), which remained high longitudinally. Patients receiving IO had higher clinical response rates and a lower rate of unplanned healthcare encounters compared to patients treated with Chemo alone. Only one-third of all patients were seen by palliative care. CONCLUSIONS: This single-center, real-world evidence study demonstrates that patients with mNSCLC experience significant distress prior to starting first-line treatment. IO treatment was associated with higher clinical benefit rates and lower healthcare utilization compared to chemotherapy. Symptom distress persists over time, highlighting potential unmet palliative and supportive care needs in mNSCLC care in the IO treatment era.

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Published In

Lung Cancer

DOI

EISSN

1872-8332

Publication Date

January 2023

Volume

175

Start / End Page

17 / 26

Location

Ireland

Related Subject Headings

  • Retrospective Studies
  • Patient Reported Outcome Measures
  • Patient Acceptance of Health Care
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • Carcinoma, Non-Small-Cell Lung
  • Adult
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

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Bodd, M. H., Locke, S. C., Wolf, S. P., Antonia, S., Crawford, J., Hartman, J., … LeBlanc, T. W. (2023). Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study. Lung Cancer, 175, 17–26. https://doi.org/10.1016/j.lungcan.2022.11.010
Bodd, Monica H., Susan C. Locke, Steve P. Wolf, Scott Antonia, Jeffrey Crawford, John Hartman, Kris W. Herring, et al. “Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study.Lung Cancer 175 (January 2023): 17–26. https://doi.org/10.1016/j.lungcan.2022.11.010.
Bodd, Monica H., et al. “Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study.Lung Cancer, vol. 175, Jan. 2023, pp. 17–26. Pubmed, doi:10.1016/j.lungcan.2022.11.010.
Bodd MH, Locke SC, Wolf SP, Antonia S, Crawford J, Hartman J, Herring KW, Ready NE, Stinchcombe TE, Troy JD, Williams C, Clarke JM, LeBlanc TW. Patient-Reported Distress and Clinical Outcomes with Immuno-Oncology Agents in Metastatic Non-Small Cell Lung Cancer (mNSCLC): A Real-World Retrospective Cohort Study. Lung Cancer. 2023 Jan;175:17–26.
Journal cover image

Published In

Lung Cancer

DOI

EISSN

1872-8332

Publication Date

January 2023

Volume

175

Start / End Page

17 / 26

Location

Ireland

Related Subject Headings

  • Retrospective Studies
  • Patient Reported Outcome Measures
  • Patient Acceptance of Health Care
  • Oncology & Carcinogenesis
  • Lung Neoplasms
  • Humans
  • Carcinoma, Non-Small-Cell Lung
  • Adult
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences