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Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.

Publication ,  Journal Article
Kam, Y-W; Simarmata, D; Chow, A; Her, Z; Teng, T-S; Ong, EKS; Rénia, L; Leo, Y-S; Ng, LFP
Published in: The Journal of infectious diseases
April 2012

Chikungunya virus (CHIKV) and related arboviruses have been responsible for large epidemic outbreaks with serious economic and social impact. Although infected individuals clear the virus from the blood, some develop debilitating and prolonged arthralgia.We investigated specificity and strength of antibody responses in a longitudinal study on CHIKV-infected patients and analyzed their association with viral load, cytokine profile, and severity.We found that CHIKV-specific response is dominated by immunoglobulin G3 (IgG3) antibodies. The antibodies were neutralizing, and patients with high viremia rapidly developed high levels of anti-CHIKV antibodies of this specific isotype. Although these patients endured a more severe disease progression during the acute viremic phase, they cleared the virus faster and did not experience persistent arthralgia. However, significant persistent arthralgia was observed in patients with low viremia who developed IgG3 at a later stage.Absence of early CHIKV-specific IgG3 may therefore serve as a specific marker of patients with increased risk of disease.

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Published In

The Journal of infectious diseases

DOI

EISSN

1537-6613

ISSN

0022-1899

Publication Date

April 2012

Volume

205

Issue

7

Start / End Page

1147 / 1154

Related Subject Headings

  • Viral Load
  • Severity of Illness Index
  • Risk Assessment
  • Prognosis
  • Middle Aged
  • Microbiology
  • Male
  • Longitudinal Studies
  • Immunoglobulin G
  • Humans
 

Citation

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Kam, Y.-W., Simarmata, D., Chow, A., Her, Z., Teng, T.-S., Ong, E. K. S., … Ng, L. F. P. (2012). Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. The Journal of Infectious Diseases, 205(7), 1147–1154. https://doi.org/10.1093/infdis/jis033
Kam, Yiu-Wing, Diane Simarmata, Angela Chow, Zhisheng Her, Terk-Shin Teng, Edward K. S. Ong, Laurent Rénia, Yee-Sin Leo, and Lisa F. P. Ng. “Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.The Journal of Infectious Diseases 205, no. 7 (April 2012): 1147–54. https://doi.org/10.1093/infdis/jis033.
Kam Y-W, Simarmata D, Chow A, Her Z, Teng T-S, Ong EKS, et al. Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. The Journal of infectious diseases. 2012 Apr;205(7):1147–54.
Kam, Yiu-Wing, et al. “Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection.The Journal of Infectious Diseases, vol. 205, no. 7, Apr. 2012, pp. 1147–54. Epmc, doi:10.1093/infdis/jis033.
Kam Y-W, Simarmata D, Chow A, Her Z, Teng T-S, Ong EKS, Rénia L, Leo Y-S, Ng LFP. Early appearance of neutralizing immunoglobulin G3 antibodies is associated with chikungunya virus clearance and long-term clinical protection. The Journal of infectious diseases. 2012 Apr;205(7):1147–1154.
Journal cover image

Published In

The Journal of infectious diseases

DOI

EISSN

1537-6613

ISSN

0022-1899

Publication Date

April 2012

Volume

205

Issue

7

Start / End Page

1147 / 1154

Related Subject Headings

  • Viral Load
  • Severity of Illness Index
  • Risk Assessment
  • Prognosis
  • Middle Aged
  • Microbiology
  • Male
  • Longitudinal Studies
  • Immunoglobulin G
  • Humans