Biomarkers for the diagnosis of deep vein thrombosis.
Venous thromboembolic disease (VTE) remains a significant source of morbidity and mortality. As non-specific subjective complaints and a paucity of objective clinical examination findings complicate the diagnosis of both deep venous thrombosis (DVT) and pulmonary embolism, diagnostic modalities remain essential. Compression ultrasound remains the gold standard for DVT diagnosis. Reliable imaging is not always available making a serologic diagnosis, or biomarker, highly desirable. While D-dimer, a highly sensitive biomarker, is useful for excluding acute VTE, it lacks the specificity necessary for diagnostic confirmation. As such, ongoing research efforts target and support the utility of alternative plasma biomarkers to aid in the diagnosis of VTE including selectins, microparticles, IL-10 and other inflammatory markers. These molecular markers may also predict recurrence risk, guide length and modality of treatment, and predict which thrombi will resolve spontaneously or recanalize, thus potentially identifying patients who would benefit from more aggressive therapies than standard anticoagulation.
Duke Scholars
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Related Subject Headings
- 3207 Medical microbiology
- 3205 Medical biochemistry and metabolomics
- 3202 Clinical sciences
- 1108 Medical Microbiology
- 1103 Clinical Sciences
- 1101 Medical Biochemistry and Metabolomics
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- 3207 Medical microbiology
- 3205 Medical biochemistry and metabolomics
- 3202 Clinical sciences
- 1108 Medical Microbiology
- 1103 Clinical Sciences
- 1101 Medical Biochemistry and Metabolomics