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Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study.

Publication ,  Journal Article
Levenback, CF; Ali, S; Coleman, RL; Gold, MA; Fowler, JM; Judson, PL; Bell, MC; De Geest, K; Spirtos, NM; Potkul, RK; Leitao, MM; Rossi, EC ...
Published in: J Clin Oncol
November 1, 2012

PURPOSE: To determine the safety of sentinel lymph node biopsy as a replacement for inguinal femoral lymphadenectomy in selected women with vulvar cancer. PATIENTS AND METHODS: Eligible women had squamous cell carcinoma, at least 1-mm invasion, and tumor size ≥ 2 cm and ≤ 6 cm. The primary tumor was limited to the vulva, and there were no groin lymph nodes that were clinically suggestive of cancer. All women underwent intraoperative lymphatic mapping, sentinel lymph node biopsy, and inguinal femoral lymphadenectomy. Histologic ultra staging of the sentinel lymph node was prescribed. RESULTS: In all, 452 women underwent the planned procedures, and 418 had at least one sentinel lymph node identified. There were 132 node-positive women, including 11 (8.3%) with false-negative nodes. Twenty-three percent of the true-positive patients were detected by immunohistochemical analysis of the sentinel lymph node. The sensitivity was 91.7% (90% lower confidence bound, 86.7%) and the false-negative predictive value (1-negative predictive value) was 3.7% (90% upper confidence bound, 6.1%). In women with tumor less than 4 cm, the false-negative predictive value was 2.0% (90% upper confidence bound, 4.5%). CONCLUSION: Sentinel lymph node biopsy is a reasonable alternative to inguinal femoral lymphadenectomy in selected women with squamous cell carcinoma of the vulva.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

November 1, 2012

Volume

30

Issue

31

Start / End Page

3786 / 3791

Location

United States

Related Subject Headings

  • Vulvar Neoplasms
  • Sentinel Lymph Node Biopsy
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphatic Metastasis
  • Lymph Nodes
  • Lymph Node Excision
  • Incidence
  • Humans
 

Citation

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MLA
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Levenback, C. F., Ali, S., Coleman, R. L., Gold, M. A., Fowler, J. M., Judson, P. L., … Trimble, C. L. (2012). Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study. J Clin Oncol, 30(31), 3786–3791. https://doi.org/10.1200/JCO.2011.41.2528
Levenback, Charles F., Shamshad Ali, Robert L. Coleman, Michael A. Gold, Jeffrey M. Fowler, Patricia L. Judson, Maria C. Bell, et al. “Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study.J Clin Oncol 30, no. 31 (November 1, 2012): 3786–91. https://doi.org/10.1200/JCO.2011.41.2528.
Levenback CF, Ali S, Coleman RL, Gold MA, Fowler JM, Judson PL, et al. Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study. J Clin Oncol. 2012 Nov 1;30(31):3786–91.
Levenback, Charles F., et al. “Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study.J Clin Oncol, vol. 30, no. 31, Nov. 2012, pp. 3786–91. Pubmed, doi:10.1200/JCO.2011.41.2528.
Levenback CF, Ali S, Coleman RL, Gold MA, Fowler JM, Judson PL, Bell MC, De Geest K, Spirtos NM, Potkul RK, Leitao MM, Bakkum-Gamez JN, Rossi EC, Lentz SS, Burke JJ, Van Le L, Trimble CL. Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study. J Clin Oncol. 2012 Nov 1;30(31):3786–3791.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

November 1, 2012

Volume

30

Issue

31

Start / End Page

3786 / 3791

Location

United States

Related Subject Headings

  • Vulvar Neoplasms
  • Sentinel Lymph Node Biopsy
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Lymphatic Metastasis
  • Lymph Nodes
  • Lymph Node Excision
  • Incidence
  • Humans