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An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.

Publication ,  Journal Article
Huang, K; Ozpinar, EW; Su, T; Tang, J; Shen, D; Qiao, L; Hu, S; Li, Z; Liang, H; Mathews, K; Scharf, V; Freytes, DO; Cheng, K
Published in: Sci Transl Med
April 8, 2020

Cell therapy has been a promising strategy for cardiac repair after injury or infarction; however, low retention and engraftment of transplanted cells limit potential therapeutic efficacy. Seeding scaffold material with cells to create cardiac patches that are transplanted onto the surface of the heart can overcome these limitations. However, because patches need to be freshly prepared to maintain cell viability, long-term storage is not feasible and limits clinical applicability. Here, we developed an off-the-shelf therapeutic cardiac patch composed of a decellularized porcine myocardial extracellular matrix scaffold and synthetic cardiac stromal cells (synCSCs) generated by encapsulating secreted factors from isolated human cardiac stromal cells. This fully acellular artificial cardiac patch (artCP) maintained its potency after long-term cryopreservation. In a rat model of acute myocardial infarction, transplantation of the artCP supported cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. The safety and efficacy of the artCP were further confirmed in a porcine model of myocardial infarction. The artCP is a clinically feasible, easy-to-store, and cell-free alternative to myocardial repair using cell-based cardiac patches.

Duke Scholars

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Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

April 8, 2020

Volume

12

Issue

538

Location

United States

Related Subject Headings

  • Swine
  • Rats
  • Myocardium
  • Myocardial Infarction
  • Heart
  • Extracellular Matrix
  • Cell- and Tissue-Based Therapy
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology
 

Citation

APA
Chicago
ICMJE
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Huang, K., Ozpinar, E. W., Su, T., Tang, J., Shen, D., Qiao, L., … Cheng, K. (2020). An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. Sci Transl Med, 12(538). https://doi.org/10.1126/scitranslmed.aat9683
Huang, Ke, Emily W. Ozpinar, Teng Su, Junnan Tang, Deliang Shen, Li Qiao, Shiqi Hu, et al. “An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.Sci Transl Med 12, no. 538 (April 8, 2020). https://doi.org/10.1126/scitranslmed.aat9683.
Huang K, Ozpinar EW, Su T, Tang J, Shen D, Qiao L, et al. An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. Sci Transl Med. 2020 Apr 8;12(538).
Huang, Ke, et al. “An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.Sci Transl Med, vol. 12, no. 538, Apr. 2020. Pubmed, doi:10.1126/scitranslmed.aat9683.
Huang K, Ozpinar EW, Su T, Tang J, Shen D, Qiao L, Hu S, Li Z, Liang H, Mathews K, Scharf V, Freytes DO, Cheng K. An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. Sci Transl Med. 2020 Apr 8;12(538).

Published In

Sci Transl Med

DOI

EISSN

1946-6242

Publication Date

April 8, 2020

Volume

12

Issue

538

Location

United States

Related Subject Headings

  • Swine
  • Rats
  • Myocardium
  • Myocardial Infarction
  • Heart
  • Extracellular Matrix
  • Cell- and Tissue-Based Therapy
  • Animals
  • 4003 Biomedical engineering
  • 3206 Medical biotechnology