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Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix.

Publication ,  Journal Article
Su, T; Liu, Y; He, H; Li, J; Lv, Y; Zhang, L; Sun, Y; Hu, C
Published in: ACS Macro Lett
November 15, 2016

Inspired by the delicate architecture of hyaline articular cartilage, we report on a biomimetic polymer hydrogel that incorporates strong intermolecular hydrogen bonding between urethane-urethane linkages as well as urethane-ester linkages. The resultant hydrogel, containing ≈75% water, can endure a compressive stress up to 56 MPa with a strain of 98%, and exhibit tunable compressive modulus (0.19-1.38 MPa), as well as toughness (3629-28290 J m-2) within a wide range. The tensile strength and elastic modulus reach as high as 0.56 and 5.5 MPa, respectively. The high stiffness and toughness enable the gel to withstand cyclic compressive loadings without fracturing. Moreover, our hydrogel mimics the extracellular matrices of cartilage and bone tissues and provides biochemical and physical cues that support the three-dimensional proliferation of chondrocytes and osteogenic differentiation of preosteoblasts.

Duke Scholars

Published In

ACS Macro Lett

DOI

EISSN

2161-1653

Publication Date

November 15, 2016

Volume

5

Issue

11

Start / End Page

1217 / 1221

Location

United States

Related Subject Headings

  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0303 Macromolecular and Materials Chemistry
 

Citation

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Su, T., Liu, Y., He, H., Li, J., Lv, Y., Zhang, L., … Hu, C. (2016). Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix. ACS Macro Lett, 5(11), 1217–1221. https://doi.org/10.1021/acsmacrolett.6b00702
Su, Teng, Yi Liu, Hongjian He, Jia Li, Yanan Lv, Lili Zhang, Yao Sun, and Chunpu Hu. “Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix.ACS Macro Lett 5, no. 11 (November 15, 2016): 1217–21. https://doi.org/10.1021/acsmacrolett.6b00702.
Su T, Liu Y, He H, Li J, Lv Y, Zhang L, et al. Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix. ACS Macro Lett. 2016 Nov 15;5(11):1217–21.
Su, Teng, et al. “Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix.ACS Macro Lett, vol. 5, no. 11, Nov. 2016, pp. 1217–21. Pubmed, doi:10.1021/acsmacrolett.6b00702.
Su T, Liu Y, He H, Li J, Lv Y, Zhang L, Sun Y, Hu C. Strong Bioinspired Polymer Hydrogel with Tunable Stiffness and Toughness for Mimicking the Extracellular Matrix. ACS Macro Lett. 2016 Nov 15;5(11):1217–1221.
Journal cover image

Published In

ACS Macro Lett

DOI

EISSN

2161-1653

Publication Date

November 15, 2016

Volume

5

Issue

11

Start / End Page

1217 / 1221

Location

United States

Related Subject Headings

  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0303 Macromolecular and Materials Chemistry