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Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats.

Publication ,  Journal Article
Chaparro, E; Quiroga, C; Erasso, D; Bosco, G; Rubini, A; Mangar, D; Camporesi, E
Published in: Journal of enzyme inhibition and medicinal chemistry
December 2014

Hypotension causes histologic changes in the hippocampal CA1 area, while behavior remains unchanged. We believe that an even stronger insult may also cause behavioral changes.We used a rat hemorrhagic shock model plus temporary hypoxia to assess functional outcome at different time points post-injury. Our hypothesis is that the damage can be attenuated by the use of isoflurane.Rats were subjected to brief hypotension. Animals were evaluated at different time points after receiving hypoxia and hypotension, with and without isoflurane treatment.The administration of isoflurane after the insult protected the animals from memory alterations. No histopatologic changes were found in any of the groups.This observation suggests that in this model of hypotension plus hypoxia there is mild cerebral damage that is reflected by memory changes. Exposure to isoflurane after the insult can prevent the onset of memory deficits.

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Published In

Journal of enzyme inhibition and medicinal chemistry

DOI

EISSN

1475-6374

ISSN

1475-6366

Publication Date

December 2014

Volume

29

Issue

6

Start / End Page

895 / 900

Related Subject Headings

  • Shock, Hemorrhagic
  • Rats, Sprague-Dawley
  • Rats
  • Nootropic Agents
  • Memory
  • Medicinal & Biomolecular Chemistry
  • Male
  • Isoflurane
  • Hypoxia
  • Hypotension
 

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Chaparro, E., Quiroga, C., Erasso, D., Bosco, G., Rubini, A., Mangar, D., & Camporesi, E. (2014). Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats. Journal of Enzyme Inhibition and Medicinal Chemistry, 29(6), 895–900. https://doi.org/10.3109/14756366.2013.866658
Chaparro, Eduardo, Carolina Quiroga, Diana Erasso, Gerardo Bosco, Alessandro Rubini, Devanand Mangar, and Enrico Camporesi. “Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats.Journal of Enzyme Inhibition and Medicinal Chemistry 29, no. 6 (December 2014): 895–900. https://doi.org/10.3109/14756366.2013.866658.
Chaparro E, Quiroga C, Erasso D, Bosco G, Rubini A, Mangar D, et al. Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats. Journal of enzyme inhibition and medicinal chemistry. 2014 Dec;29(6):895–900.
Chaparro, Eduardo, et al. “Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats.Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 29, no. 6, Dec. 2014, pp. 895–900. Epmc, doi:10.3109/14756366.2013.866658.
Chaparro E, Quiroga C, Erasso D, Bosco G, Rubini A, Mangar D, Camporesi E. Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats. Journal of enzyme inhibition and medicinal chemistry. 2014 Dec;29(6):895–900.

Published In

Journal of enzyme inhibition and medicinal chemistry

DOI

EISSN

1475-6374

ISSN

1475-6366

Publication Date

December 2014

Volume

29

Issue

6

Start / End Page

895 / 900

Related Subject Headings

  • Shock, Hemorrhagic
  • Rats, Sprague-Dawley
  • Rats
  • Nootropic Agents
  • Memory
  • Medicinal & Biomolecular Chemistry
  • Male
  • Isoflurane
  • Hypoxia
  • Hypotension