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Metabolic syndrome is associated with aggressive prostate cancer regardless of race.

Publication ,  Journal Article
Guerrios-Rivera, L; Howard, LE; Wiggins, EK; Hoyo, C; Grant, DJ; Erickson, TR; Ithisuphalap, J; Freedland, AR; Vidal, AC; Fowke, JH; Freedland, SJ
Published in: Cancer causes & control : CCC
March 2023

Recent meta-analyses suggest the Metabolic Syndrome (MS) increases high-grade prostate cancer (PC), although studies are inconsistent and few black men were included. We investigated MS and PC diagnosis in black and white men undergoing prostate biopsy in an equal access healthcare system. We hypothesized MS would be linked with aggressive PC, regardless of race.Among men undergoing prostate biopsy at the Durham Veterans Affairs Hospital, medical record data abstraction of diagnosis or treatment for hypertension (≥ 130/85 mmHg), dyslipidemia (HDL < 40 mg/dL), hypertriglyceridemia (≥ 150 mg/dL), diabetes, hyperglycemia (fasting glucose ≥ 100 ml/dL), and central obesity (waist circumference ≥ 40 inches) were done. Biopsy grade group (GG) was categorized as low (GG1) or high (GG2-5). Multinomial logistic regression was used to examine MS (3-5 components) vs. no MS (0-2 components) and diagnosis of high grade and low grade vs. no PC, adjusting for potential confounders. Interactions between race and MS were also tested.Of 1,051 men (57% black), 532 (51%) had MS. Men with MS were older, more likely to be non-black, and had a larger prostate volume (all p ≤ 0.011). On multivariable analysis, MS was associated with high-grade PC (OR = 1.73, 95% CI 1.21-2.48, p = 0.003), but not overall PC (OR = 1.17, 95% CI 0.88-1.57, p = 0.29) or low grade (OR = 0.87, 95% CI 0.62-1.21, p = 0.39). Results were similar in black and non-black men (all p-interactions > 0.25).Our data suggest that metabolic dysregulation advances an aggressive PC diagnosis in both black and non-black men. If confirmed, prevention of MS could reduce the risk of developing aggressive PC, including black men at higher risk of PC mortality.

Duke Scholars

Published In

Cancer causes & control : CCC

DOI

EISSN

1573-7225

ISSN

0957-5243

Publication Date

March 2023

Volume

34

Issue

3

Start / End Page

213 / 221

Related Subject Headings

  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Obesity
  • Metabolic Syndrome
  • Male
  • Humans
  • Epidemiology
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis
 

Citation

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Guerrios-Rivera, L., Howard, L. E., Wiggins, E. K., Hoyo, C., Grant, D. J., Erickson, T. R., … Freedland, S. J. (2023). Metabolic syndrome is associated with aggressive prostate cancer regardless of race. Cancer Causes & Control : CCC, 34(3), 213–221. https://doi.org/10.1007/s10552-022-01649-9
Guerrios-Rivera, Lourdes, Lauren E. Howard, Emily K. Wiggins, Cathrine Hoyo, Delores J. Grant, Tyler R. Erickson, Jaruda Ithisuphalap, et al. “Metabolic syndrome is associated with aggressive prostate cancer regardless of race.Cancer Causes & Control : CCC 34, no. 3 (March 2023): 213–21. https://doi.org/10.1007/s10552-022-01649-9.
Guerrios-Rivera L, Howard LE, Wiggins EK, Hoyo C, Grant DJ, Erickson TR, et al. Metabolic syndrome is associated with aggressive prostate cancer regardless of race. Cancer causes & control : CCC. 2023 Mar;34(3):213–21.
Guerrios-Rivera, Lourdes, et al. “Metabolic syndrome is associated with aggressive prostate cancer regardless of race.Cancer Causes & Control : CCC, vol. 34, no. 3, Mar. 2023, pp. 213–21. Epmc, doi:10.1007/s10552-022-01649-9.
Guerrios-Rivera L, Howard LE, Wiggins EK, Hoyo C, Grant DJ, Erickson TR, Ithisuphalap J, Freedland AR, Vidal AC, Fowke JH, Freedland SJ. Metabolic syndrome is associated with aggressive prostate cancer regardless of race. Cancer causes & control : CCC. 2023 Mar;34(3):213–221.
Journal cover image

Published In

Cancer causes & control : CCC

DOI

EISSN

1573-7225

ISSN

0957-5243

Publication Date

March 2023

Volume

34

Issue

3

Start / End Page

213 / 221

Related Subject Headings

  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prostate
  • Obesity
  • Metabolic Syndrome
  • Male
  • Humans
  • Epidemiology
  • 4202 Epidemiology
  • 3211 Oncology and carcinogenesis