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Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial.

Publication ,  Journal Article
Thomas, AS; Duchateau, L; Kozma-Wiebe, P; Jaffe, G
Published in: Br J Ophthalmol
July 2023

BACKGROUND/AIMS: To describe the clinical impact of external limiting membrane (ELM) disruption, ellipsoid zone (EZ) disruption and subretinal fluid (SRF) seen on optical coherence tomography (OCT) in eyes with vitreomacular traction (VMT) without macular hole (MH) in the Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole study. METHODS: Phase 3b randomised double-blind sham-controlled multicentre study including 144 eyes with VMT without MH. Eyes were randomised to receive a single intravitreal injection of ocriplasmin or sham injection and were followed for 24 months. Eyes were analysed for presence, course and clinical impact of ELM disruption, EZ disruption and SRF on OCT. RESULTS: ELM disruption, EZ disruption and SRF were present in 32.6%, 52.2% and 45.8% of ocriplasmin-treated eyes and 39.6%, 42.6% and 37.5% of sham-treated eyes at baseline. VMT resolution was associated with resolution of ELM and EZ disruption and SRF. A small number of eyes had persistent ELM disruption, EZ disruption and/or SRF at the seventh visit or later (17 months or later) following medical or surgical VMT resolution. Resolution of ELM disruption, EZ disruption and/or SRF was associated with an improvement of visual acuity from baseline. Following VMT resolution, ELM recovery usually preceded EZ recovery and SRF resolution. CONCLUSIONS: ELM disruption, EZ disruption and/or SRF are present in a significant percentage of eyes with VMT without MH. Release of VMT is usually associated with outer retinal recovery and an associated improvement in visual acuity. ELM recovery typically precedes EZ recovery and SRF resolution following VMT release.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

July 2023

Volume

107

Issue

7

Start / End Page

1012 / 1017

Location

England

Related Subject Headings

  • Treatment Outcome
  • Traction
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Perforations
  • Retinal Diseases
  • Retina
  • Peptide Fragments
  • Ophthalmology & Optometry
  • Intravitreal Injections
 

Citation

APA
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ICMJE
MLA
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Thomas, A. S., Duchateau, L., Kozma-Wiebe, P., & Jaffe, G. (2023). Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial. Br J Ophthalmol, 107(7), 1012–1017. https://doi.org/10.1136/bjophthalmol-2021-319500
Thomas, Akshay S., Luc Duchateau, Petra Kozma-Wiebe, and Glenn Jaffe. “Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial.Br J Ophthalmol 107, no. 7 (July 2023): 1012–17. https://doi.org/10.1136/bjophthalmol-2021-319500.
Thomas AS, Duchateau L, Kozma-Wiebe P, Jaffe G. Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial. Br J Ophthalmol. 2023 Jul;107(7):1012–7.
Thomas, Akshay S., et al. “Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial.Br J Ophthalmol, vol. 107, no. 7, July 2023, pp. 1012–17. Pubmed, doi:10.1136/bjophthalmol-2021-319500.
Thomas AS, Duchateau L, Kozma-Wiebe P, Jaffe G. Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial. Br J Ophthalmol. 2023 Jul;107(7):1012–1017.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

July 2023

Volume

107

Issue

7

Start / End Page

1012 / 1017

Location

England

Related Subject Headings

  • Treatment Outcome
  • Traction
  • Tomography, Optical Coherence
  • Retrospective Studies
  • Retinal Perforations
  • Retinal Diseases
  • Retina
  • Peptide Fragments
  • Ophthalmology & Optometry
  • Intravitreal Injections