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Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes.

Publication ,  Journal Article
Kittipibul, V; Yaranov, DM; Jefferies, JL; Silver, MA; Burkhoff, D; Rao, VN; Biegus, J; Ponikowski, P; Fudim, M
Published in: J Cardiovasc Transl Res
June 2023

Studies have shown poor correlation between intra-cardiac pressures and blood volume (BV) measurements including HF. The impact of sex and left ventricular ejection fraction (LVEF) on this relationship has not been studied. We obtained pressure (pulmonary artery diastolic pressure (PADP)) and volume (total blood volume (TBV) and estimated stress blood volume (eSBV)) measurements from HF patients at the time of CardioMEMS implantation. A total of 20 patients were included. There was no significant difference between PADP, TBV, and eSBV between sexes. There was only a moderate correlation between PADP and eSBV in men but not in women or with TBV in both sexes. HFrEF had higher PADP and eSBV than HFpEF. There was a consistent lack of correlation between PADP and both TBV and eSBV. Further studies evaluating mid- to long-term implications of pressure-volume profiles as well as changes following decongestion therapy are warranted to better understand the pressure-volume interplay and determine appropriate decongestion strategy for each pressure-volume phenotype.

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

June 2023

Volume

16

Issue

3

Start / End Page

751 / 753

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Prognosis
  • Male
  • Humans
  • Heart Failure
  • Female
  • Blood Volume
  • 3201 Cardiovascular medicine and haematology
 

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Kittipibul, V., Yaranov, D. M., Jefferies, J. L., Silver, M. A., Burkhoff, D., Rao, V. N., … Fudim, M. (2023). Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes. J Cardiovasc Transl Res, 16(3), 751–753. https://doi.org/10.1007/s12265-022-10345-7
Kittipibul, Veraprapas, Dmitry M. Yaranov, John L. Jefferies, Marc A. Silver, Daniel Burkhoff, Vishal N. Rao, Jan Biegus, Piotr Ponikowski, and Marat Fudim. “Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes.J Cardiovasc Transl Res 16, no. 3 (June 2023): 751–53. https://doi.org/10.1007/s12265-022-10345-7.
Kittipibul V, Yaranov DM, Jefferies JL, Silver MA, Burkhoff D, Rao VN, et al. Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes. J Cardiovasc Transl Res. 2023 Jun;16(3):751–3.
Kittipibul, Veraprapas, et al. “Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes.J Cardiovasc Transl Res, vol. 16, no. 3, June 2023, pp. 751–53. Pubmed, doi:10.1007/s12265-022-10345-7.
Kittipibul V, Yaranov DM, Jefferies JL, Silver MA, Burkhoff D, Rao VN, Biegus J, Ponikowski P, Fudim M. Pressure-Volume Profiles in Heart Failure Across Sexes and Phenotypes. J Cardiovasc Transl Res. 2023 Jun;16(3):751–753.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

June 2023

Volume

16

Issue

3

Start / End Page

751 / 753

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Prognosis
  • Male
  • Humans
  • Heart Failure
  • Female
  • Blood Volume
  • 3201 Cardiovascular medicine and haematology