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Identification of diverse papillomaviruses in captive black-and-white ruffed lemurs (Varecia variegata).

Publication ,  Journal Article
Paietta, EN; Kraberger, S; Custer, JM; Vargas, KL; Van Doorslaer, K; Yoder, AD; Varsani, A
Published in: Archives of virology
December 2022

Papillomaviruses (PVs) are host-species-specific and tissue-specific viruses that infect a diverse array of vertebrate hosts, including humans and non-human primates, with varying pathogenic outcomes. Although primate PVs have been studied extensively, no complete genome sequences of PVs from lemurs have been determined to date. Saliva samples from three critically endangered, captive black-and-white ruffed lemurs (Varecia variegata variegata) at the Duke Lemur Center (USA) were analyzed, using high-throughput sequencing, for the presence of oral papillomaviruses. We identified three PVs from two individuals, one of which had a coinfection with two different PVs. Two of the three PVs share 99.6% nucleotide sequence identity, and we have named these isolates "Varecia variegata papillomavirus 1" (VavPV1). The third PV shares ~63% nucleotide sequence identity with VavPV1, and thus, we have named it "Varecia variegata papillomavirus 2" (VavPV2). Based on their E1 + E2 + L1 protein sequence phylogeny, the VavPVs form a distinct clade. This clade likely represents a novel genus, with VavPV1 and VavPV2 belonging to two distinct species. Our findings represent the first complete genome sequences of PVs found in lemuriform primates, with their presence suggesting the potential existence of diverse PVs across the over 100 species of lemurs.

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Published In

Archives of virology

DOI

EISSN

1432-8798

ISSN

0304-8608

Publication Date

December 2022

Volume

168

Issue

1

Start / End Page

13

Related Subject Headings

  • Virology
  • Primates
  • Lemuridae
  • Lemur
  • Humans
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 30 Agricultural, veterinary and food sciences
  • 11 Medical and Health Sciences
 

Citation

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Paietta, E. N., Kraberger, S., Custer, J. M., Vargas, K. L., Van Doorslaer, K., Yoder, A. D., & Varsani, A. (2022). Identification of diverse papillomaviruses in captive black-and-white ruffed lemurs (Varecia variegata). Archives of Virology, 168(1), 13. https://doi.org/10.1007/s00705-022-05679-1
Paietta, Elise N., Simona Kraberger, Joy M. Custer, Karla L. Vargas, Koenraad Van Doorslaer, Anne D. Yoder, and Arvind Varsani. “Identification of diverse papillomaviruses in captive black-and-white ruffed lemurs (Varecia variegata).Archives of Virology 168, no. 1 (December 2022): 13. https://doi.org/10.1007/s00705-022-05679-1.
Paietta EN, Kraberger S, Custer JM, Vargas KL, Van Doorslaer K, Yoder AD, et al. Identification of diverse papillomaviruses in captive black-and-white ruffed lemurs (Varecia variegata). Archives of virology. 2022 Dec;168(1):13.
Paietta, Elise N., et al. “Identification of diverse papillomaviruses in captive black-and-white ruffed lemurs (Varecia variegata).Archives of Virology, vol. 168, no. 1, Dec. 2022, p. 13. Epmc, doi:10.1007/s00705-022-05679-1.
Paietta EN, Kraberger S, Custer JM, Vargas KL, Van Doorslaer K, Yoder AD, Varsani A. Identification of diverse papillomaviruses in captive black-and-white ruffed lemurs (Varecia variegata). Archives of virology. 2022 Dec;168(1):13.
Journal cover image

Published In

Archives of virology

DOI

EISSN

1432-8798

ISSN

0304-8608

Publication Date

December 2022

Volume

168

Issue

1

Start / End Page

13

Related Subject Headings

  • Virology
  • Primates
  • Lemuridae
  • Lemur
  • Humans
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 30 Agricultural, veterinary and food sciences
  • 11 Medical and Health Sciences