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Vaccine-acquired rotavirus in infants with severe combined immunodeficiency

Publication ,  Journal Article
Patel, NC; Hertel, PM; Estes, MK; De La Morena, M; Petru, AM; Noroski, LM; Revell, PA; Hanson, IC; Paul, ME; Rosenblatt, HM; Abramson, SL
Published in: New England Journal of Medicine
January 28, 2010

Live pentavalent human-bovine reassortant rotavirus vaccine is recommended in the United States for routine immunization of infants. We describe three infants, two with failure to thrive, who had dehydration and diarrhea within 1 month after their first or second rotavirus immunization and subsequently received a diagnosis of severe combined immunodeficiency. Rotavirus was detected, by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay, in stool specimens obtained from all three infants, and gene-sequence analysis revealed the presence of vaccine rotavirus. These infections raise concerns regarding the safety of rotavirus vaccine in severely immunocompromised patients. Copyright © 2010 Massachusetts Medical Society. All rights reserved.

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Published In

New England Journal of Medicine

DOI

EISSN

1533-4406

ISSN

0028-4793

Publication Date

January 28, 2010

Volume

362

Issue

4

Start / End Page

314 / 319

Related Subject Headings

  • General & Internal Medicine
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, N. C., Hertel, P. M., Estes, M. K., De La Morena, M., Petru, A. M., Noroski, L. M., … Abramson, S. L. (2010). Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. New England Journal of Medicine, 362(4), 314–319. https://doi.org/10.1056/NEJMoa0904485
Patel, N. C., P. M. Hertel, M. K. Estes, M. De La Morena, A. M. Petru, L. M. Noroski, P. A. Revell, et al. “Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.” New England Journal of Medicine 362, no. 4 (January 28, 2010): 314–19. https://doi.org/10.1056/NEJMoa0904485.
Patel NC, Hertel PM, Estes MK, De La Morena M, Petru AM, Noroski LM, et al. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. New England Journal of Medicine. 2010 Jan 28;362(4):314–9.
Patel, N. C., et al. “Vaccine-acquired rotavirus in infants with severe combined immunodeficiency.” New England Journal of Medicine, vol. 362, no. 4, Jan. 2010, pp. 314–19. Scopus, doi:10.1056/NEJMoa0904485.
Patel NC, Hertel PM, Estes MK, De La Morena M, Petru AM, Noroski LM, Revell PA, Hanson IC, Paul ME, Rosenblatt HM, Abramson SL. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. New England Journal of Medicine. 2010 Jan 28;362(4):314–319.

Published In

New England Journal of Medicine

DOI

EISSN

1533-4406

ISSN

0028-4793

Publication Date

January 28, 2010

Volume

362

Issue

4

Start / End Page

314 / 319

Related Subject Headings

  • General & Internal Medicine
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences