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Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.

Publication ,  Journal Article
Rahangdale, L; De Paris, K; Kashuba, ADM; Nelson, JAE; Cottrell, M; Sykes, C; Emerson, C; Young, SL; Stevens, T; Patterson, KB; Cohen, MS
Published in: J Acquir Immune Defic Syndr
April 1, 2015

: A comparative analysis of cellular and soluble markers of immune activation in HIV-infected women on combination antiretroviral therapy showed that the upper genital tract (UGT) compared to the lower female genital tract was characterized by higher frequencies of potential HIV target cells and increased inflammatory molecules. Despite the activated UGT milieu, HIV RNA could not be detected in paired samples of plasma, cervicovaginal or endometrial lavage. As antiretroviral concentrations were ≥3-fold higher in the endometrium than in the lower genital tract, high antiretroviral penetration and/or metabolism may limit viral replication in the UGT.

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Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

April 1, 2015

Volume

68

Issue

4

Start / End Page

420 / 424

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Reproductive Tract Infections
  • Middle Aged
  • Humans
  • HIV Infections
  • Female
  • Endometrium
  • Anti-Retroviral Agents
  • Adult
 

Citation

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Rahangdale, L., De Paris, K., Kashuba, A. D. M., Nelson, J. A. E., Cottrell, M., Sykes, C., … Cohen, M. S. (2015). Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr, 68(4), 420–424. https://doi.org/10.1097/QAI.0000000000000480
Rahangdale, Lisa, Kristina De Paris, Angela D. M. Kashuba, Julie A. E. Nelson, Mackenzie Cottrell, Craig Sykes, Cindi Emerson, et al. “Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.J Acquir Immune Defic Syndr 68, no. 4 (April 1, 2015): 420–24. https://doi.org/10.1097/QAI.0000000000000480.
Rahangdale L, De Paris K, Kashuba ADM, Nelson JAE, Cottrell M, Sykes C, et al. Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):420–4.
Rahangdale, Lisa, et al. “Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women.J Acquir Immune Defic Syndr, vol. 68, no. 4, Apr. 2015, pp. 420–24. Pubmed, doi:10.1097/QAI.0000000000000480.
Rahangdale L, De Paris K, Kashuba ADM, Nelson JAE, Cottrell M, Sykes C, Emerson C, Young SL, Stevens T, Patterson KB, Cohen MS. Immunologic, virologic, and pharmacologic characterization of the female upper genital tract in HIV-infected women. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):420–424.

Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

April 1, 2015

Volume

68

Issue

4

Start / End Page

420 / 424

Location

United States

Related Subject Headings

  • Young Adult
  • Virology
  • Reproductive Tract Infections
  • Middle Aged
  • Humans
  • HIV Infections
  • Female
  • Endometrium
  • Anti-Retroviral Agents
  • Adult