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Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study.

Publication ,  Journal Article
Jordan, CD; Glover, LM; Gao, Y; Musani, SK; Mwasongwe, S; Wilson, JG; Reiner, A; Diez-Roux, A; Sims, M
Published in: Stress Health
April 2019

Leukocyte telomere length (LTL) is a biomarker of cellular aging. African Americans report more stress than other groups; however, the association of psychosocial stressors with biological aging among African Americans remains unclear. The current study evaluated the association of psychosocial factors (negative affect and stressors) with LTL in a large sample of African American men and women (n = 2,516) from the Jackson Heart Study. Using multivariable linear regression, we examined the sex-specific associations of psychosocial factors (cynical distrust, anger in and out, depressive symptoms, negative affect summary scores, global stress, weekly stress, major life events, and stress summary scores) with LTL. Model 1 adjusted for demographics and education. Model 2 adjusted for model 1, smoking, alcohol intake, physical activity, diabetes, hypertension, and high-sensitivity C-reactive protein. Among women, high (vs. low) cynical distrust was associated with shorter mean LTL in model 1 (b = -0.12; p = 0.039). Additionally, high (vs. low) anger out and expressed negative affect summary scores were associated with shorter LTL among women after full adjustment (b = -0.13; p = 0.011; b = -0.12, p = 0.031, respectively). High levels of cynical distrust, anger out, and negative affect summary scores may be risk factors for shorter LTL, particularly among African-American women.

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Published In

Stress Health

DOI

EISSN

1532-2998

Publication Date

April 2019

Volume

35

Issue

2

Start / End Page

138 / 145

Location

England

Related Subject Headings

  • Trust
  • Telomere Shortening
  • Stress, Psychological
  • Risk Factors
  • Psychiatry
  • Multivariate Analysis
  • Mississippi
  • Middle Aged
  • Male
  • Longitudinal Studies
 

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Jordan, C. D., Glover, L. M., Gao, Y., Musani, S. K., Mwasongwe, S., Wilson, J. G., … Sims, M. (2019). Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study. Stress Health, 35(2), 138–145. https://doi.org/10.1002/smi.2848
Jordan, Christina D., LáShauntá M. Glover, Yan Gao, Solomon K. Musani, Stanford Mwasongwe, James G. Wilson, Alex Reiner, Ana Diez-Roux, and Mario Sims. “Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study.Stress Health 35, no. 2 (April 2019): 138–45. https://doi.org/10.1002/smi.2848.
Jordan CD, Glover LM, Gao Y, Musani SK, Mwasongwe S, Wilson JG, et al. Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study. Stress Health. 2019 Apr;35(2):138–45.
Jordan, Christina D., et al. “Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study.Stress Health, vol. 35, no. 2, Apr. 2019, pp. 138–45. Pubmed, doi:10.1002/smi.2848.
Jordan CD, Glover LM, Gao Y, Musani SK, Mwasongwe S, Wilson JG, Reiner A, Diez-Roux A, Sims M. Association of psychosocial factors with leukocyte telomere length among African Americans in the Jackson Heart Study. Stress Health. 2019 Apr;35(2):138–145.
Journal cover image

Published In

Stress Health

DOI

EISSN

1532-2998

Publication Date

April 2019

Volume

35

Issue

2

Start / End Page

138 / 145

Location

England

Related Subject Headings

  • Trust
  • Telomere Shortening
  • Stress, Psychological
  • Risk Factors
  • Psychiatry
  • Multivariate Analysis
  • Mississippi
  • Middle Aged
  • Male
  • Longitudinal Studies