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Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila.

Publication ,  Journal Article
Chakraborty, A; Peterson, NG; King, JS; Gross, RT; Pla, MM; Thennavan, A; Zhou, KC; DeLuca, S; Bursac, N; Bowles, DE; Wolf, MJ; Fox, DT
Published in: bioRxiv
February 11, 2023

Developmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tissue. We highlight a conserved asymmetry in polyploidy level between cardiac chambers in Drosophila larvae and humans. In Drosophila , differential Insulin Receptor (InR) sensitivity leads the heart chamber to reach a higher ploidy/cell size relative to the aorta chamber. Cardiac ploidy-reduced animals exhibit reduced heart chamber size, stroke volume, cardiac output, and acceleration of circulating hemocytes. These Drosophila phenotypes mimic systemic human heart failure. Using human donor hearts, we reveal asymmetry in nuclear volume (ploidy) and insulin signaling between the left ventricle and atrium. Our results identify productive and likely conserved roles for polyploidy in cardiac chambers and suggest precise ploidy levels sculpt many developing tissues. These findings of productive cardiomyocyte polyploidy impact efforts to block developmental polyploidy to improve heart injury recovery.

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bioRxiv

DOI

Publication Date

February 11, 2023

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United States
 

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Chakraborty, A., Peterson, N. G., King, J. S., Gross, R. T., Pla, M. M., Thennavan, A., … Fox, D. T. (2023). Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila. BioRxiv. https://doi.org/10.1101/2023.02.10.528086
Chakraborty, Archan, Nora G. Peterson, Juliet S. King, Ryan T. Gross, Michelle Mendiola Pla, Aatish Thennavan, Kevin C. Zhou, et al. “Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila.BioRxiv, February 11, 2023. https://doi.org/10.1101/2023.02.10.528086.
Chakraborty A, Peterson NG, King JS, Gross RT, Pla MM, Thennavan A, et al. Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila. bioRxiv. 2023 Feb 11;
Chakraborty, Archan, et al. “Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila.BioRxiv, Feb. 2023. Pubmed, doi:10.1101/2023.02.10.528086.
Chakraborty A, Peterson NG, King JS, Gross RT, Pla MM, Thennavan A, Zhou KC, DeLuca S, Bursac N, Bowles DE, Wolf MJ, Fox DT. Conserved Chamber-Specific Polyploidy Maintains Heart Function in Drosophila. bioRxiv. 2023 Feb 11;

Published In

bioRxiv

DOI

Publication Date

February 11, 2023

Location

United States