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Use of vasopressors for septic shock in the neonatal intensive care unit.

Publication ,  Journal Article
Foote, HP; Benjamin, DK; Greenberg, RG; Clark, RH; Hornik, CP
Published in: J Perinatol
October 2023

OBJECTIVE: To describe outcomes for infants in the neonatal intensive care unit with septic shock based on the vasopressor administered. METHODS: This is a multicenter cohort study of infants with an episode of septic shock. We evaluated the primary outcomes of mortality and pressor-free days alive in the first week after shock using multivariable logistic and Poisson regressions. RESULTS: We identified 1592 infants. Mortality was 50%. Dopamine was the most used vasopressor (92% of episodes) and hydrocortisone was co-administered with a vasopressor in 38% of episodes. Compared to infants treated with dopamine alone, adjusted odds of mortality were significantly higher for those treated with epinephrine alone (aOR 4.7 [95% CI: 2.3-9.2]). Adjuvant hydrocortisone was associated with significantly lower adjusted odds of mortality (aOR 0.60 [0.42-0.86]) CONCLUSIONS: The use of epinephrine as either a solo agent or in combination therapy was associated with significantly worse outcomes, while adjuvant hydrocortisone was associated with decreased mortality.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

October 2023

Volume

43

Issue

10

Start / End Page

1274 / 1280

Location

United States

Related Subject Headings

  • Vasoconstrictor Agents
  • Shock, Septic
  • Retrospective Studies
  • Pediatrics
  • Intensive Care Units, Neonatal
  • Intensive Care Units
  • Infant, Newborn
  • Hydrocortisone
  • Humans
  • Epinephrine
 

Citation

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Foote, H. P., Benjamin, D. K., Greenberg, R. G., Clark, R. H., & Hornik, C. P. (2023). Use of vasopressors for septic shock in the neonatal intensive care unit. J Perinatol, 43(10), 1274–1280. https://doi.org/10.1038/s41372-023-01667-8
Foote, Henry P., Daniel K. Benjamin, Rachel G. Greenberg, Reese H. Clark, and Christoph P. Hornik. “Use of vasopressors for septic shock in the neonatal intensive care unit.J Perinatol 43, no. 10 (October 2023): 1274–80. https://doi.org/10.1038/s41372-023-01667-8.
Foote HP, Benjamin DK, Greenberg RG, Clark RH, Hornik CP. Use of vasopressors for septic shock in the neonatal intensive care unit. J Perinatol. 2023 Oct;43(10):1274–80.
Foote, Henry P., et al. “Use of vasopressors for septic shock in the neonatal intensive care unit.J Perinatol, vol. 43, no. 10, Oct. 2023, pp. 1274–80. Pubmed, doi:10.1038/s41372-023-01667-8.
Foote HP, Benjamin DK, Greenberg RG, Clark RH, Hornik CP. Use of vasopressors for septic shock in the neonatal intensive care unit. J Perinatol. 2023 Oct;43(10):1274–1280.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

October 2023

Volume

43

Issue

10

Start / End Page

1274 / 1280

Location

United States

Related Subject Headings

  • Vasoconstrictor Agents
  • Shock, Septic
  • Retrospective Studies
  • Pediatrics
  • Intensive Care Units, Neonatal
  • Intensive Care Units
  • Infant, Newborn
  • Hydrocortisone
  • Humans
  • Epinephrine