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Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status.

Publication ,  Journal Article
Maguire, S; Al-Emadi, S; Alba, P; Aguiar, MC; Al Lawati, T; Alle, G; Bermas, B; Bhana, S; Branimir, A; Bulina, I; Clowse, M; Cogo, K; Cook, C ...
Published in: Rheumatology (Oxford)
April 3, 2023

OBJECTIVE: To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. METHODS: Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020-25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher's exact test. RESULTS: There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). CONCLUSIONS: In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy.

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Published In

Rheumatology (Oxford)

DOI

EISSN

1462-0332

Publication Date

April 3, 2023

Volume

62

Issue

4

Start / End Page

1621 / 1626

Location

England

Related Subject Headings

  • Vaccination
  • Rheumatic Diseases
  • Premature Birth
  • Pregnancy
  • Infant, Newborn
  • Humans
  • Female
  • COVID-19 Vaccines
  • COVID-19 Testing
  • COVID-19
 

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Chicago
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Maguire, S., Al-Emadi, S., Alba, P., Aguiar, M. C., Al Lawati, T., Alle, G., … Conway, R. (2023). Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status. Rheumatology (Oxford), 62(4), 1621–1626. https://doi.org/10.1093/rheumatology/keac534
Maguire, Sinead, Samar Al-Emadi, Paula Alba, Mathia Cecilia Aguiar, Talal Al Lawati, Gelsomina Alle, Bonnie Bermas, et al. “Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status.Rheumatology (Oxford) 62, no. 4 (April 3, 2023): 1621–26. https://doi.org/10.1093/rheumatology/keac534.
Maguire S, Al-Emadi S, Alba P, Aguiar MC, Al Lawati T, Alle G, et al. Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status. Rheumatology (Oxford). 2023 Apr 3;62(4):1621–6.
Maguire, Sinead, et al. “Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status.Rheumatology (Oxford), vol. 62, no. 4, Apr. 2023, pp. 1621–26. Pubmed, doi:10.1093/rheumatology/keac534.
Maguire S, Al-Emadi S, Alba P, Aguiar MC, Al Lawati T, Alle G, Bermas B, Bhana S, Branimir A, Bulina I, Clowse M, Cogo K, Colunga I, Cook C, Cortez KJ, Dao K, Gianfrancesco M, Gore-Massey M, Gossec L, Grainger R, Hausman J, Hsu TYT, Hyrich K, Isnardi C, Kawano Y, Kilding R, Kusevich DA, Lawson-Tovey S, Liew J, McCarthy E, Montgumery A, Moyano S, Nasir N, Padjen I, Papagoras C, Patel NJ, Pera M, Pisoni C, Pons-Estel G, Quiambao AL, Quintana R, Ruderman E, Sattui S, Savio V, Sciascia S, Sencarova M, Morales RS, Siddique F, Sirotich E, Sparks J, Strangfeld A, Sufka P, Tanner H, Tissera Y, Wallace Z, Werner ML, Wise L, Worthing AB, Zell J, Zepa J, Machado PM, Yazdany J, Robinson P, Conway R. Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status. Rheumatology (Oxford). 2023 Apr 3;62(4):1621–1626.
Journal cover image

Published In

Rheumatology (Oxford)

DOI

EISSN

1462-0332

Publication Date

April 3, 2023

Volume

62

Issue

4

Start / End Page

1621 / 1626

Location

England

Related Subject Headings

  • Vaccination
  • Rheumatic Diseases
  • Premature Birth
  • Pregnancy
  • Infant, Newborn
  • Humans
  • Female
  • COVID-19 Vaccines
  • COVID-19 Testing
  • COVID-19