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Abstract 4900: Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet

Publication ,  Conference
Freedland, S; Lin, P-H; Chen, EY; Tolstikov, V; Chi, J-T; Sarangarajan, R; Narain, NR; Kiebish, MA
Published in: Cancer Research
July 1, 2019

Background: Prostate cancer (PrCa) is one of the most common cancers among men and managed through surgery, hormonal therapy, chemotherapy, radiation, and cryotherapy. Depending on the stage of PrCa, androgen deprivation therapy (ADT) is commonly utilized as an intervention. ADT has proven effective in intervening in PrCa progression, although there are several side effects. Recently, the use of low carb diets has been shown to alter patients’ metabolic phenotype and as such may reduce the side effects of ADT.Methods: In this study 35 men, who were beginning ADT, were randomized to low carb diet intervention with recommended exercise or control (no lifestyle change) for 6 months. Primary results have been reported showing significant weight loss at both 3-month (17lb, p<0.01) and 6-month (23 lbs, p<0.01) and improved insulin control at 3-month (HOMA=-19 as compared to baseline, p=0.02) but not at 6-month (HOMA=-4 as compared to baseline, p=0.13). For this exploratory analysis, sera collected at baseline, 3, and 6 months was used for metabolomics analysis utilizing GC/MS TOF, QqQ LC-HILIC-MS/MS, and TripleTOF 6600 LC-RP-MS and lipidomics analysis using TripleTOF 5600+ MS/MSALL workflows to quantify the chemical diversity of the metabolome and lipidome.Results: Over 450 metabolites and 1000 lipid species were quantified. Metabolomics analysis of sera from the control patients (ADT alone) demonstrated alterations in steroid biosynthesis, androgen/estrogen metabolism, fatty acid metabolism, and lysine degradation. Lipidomics analysis of the control patients demonstrated changes in selective long chain polyunsaturated phosphatidylcholine species. Analysis of the ADT plus low carb patients revealed a change in pyruvate, glucose-alanine cycle, selenoamino acid, phenylalanine/tyrosine, and taurine metabolism. Further, lipidomic analysis revealed changes in several triglycerides, plasmalenylethanolamine, and phosphatidic acid species.Conclusion: In summary, integration of metabolomic and lipidomic analysis in hormonal and metabolic interventions of PrCa patients revealed dynamic changes providing novel insight for tailoring therapeutic intervention and monitoring.Citation Format: Stephen Freedland, Pao-Hwa Lin, Emily Y. Chen, Vladimir Tolstikov, Jen-Tsan Chi, Rangaprasad Sarangarajan, Niven R. Narain, Michael A. Kiebish. Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4900.

Duke Scholars

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

July 1, 2019

Volume

79

Issue

13_Supplement

Start / End Page

4900 / 4900

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

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Freedland, S., Lin, P.-H., Chen, E. Y., Tolstikov, V., Chi, J.-T., Sarangarajan, R., … Kiebish, M. A. (2019). Abstract 4900: Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet. In Cancer Research (Vol. 79, pp. 4900–4900). American Association for Cancer Research (AACR). https://doi.org/10.1158/1538-7445.am2019-4900
Freedland, Stephen, Pao-Hwa Lin, Emily Y. Chen, Vladimir Tolstikov, Jen-Tsan Chi, Rangaprasad Sarangarajan, Niven R. Narain, and Michael A. Kiebish. “Abstract 4900: Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet.” In Cancer Research, 79:4900–4900. American Association for Cancer Research (AACR), 2019. https://doi.org/10.1158/1538-7445.am2019-4900.
Freedland S, Lin P-H, Chen EY, Tolstikov V, Chi J-T, Sarangarajan R, et al. Abstract 4900: Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet. In: Cancer Research. American Association for Cancer Research (AACR); 2019. p. 4900–4900.
Freedland, Stephen, et al. “Abstract 4900: Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet.” Cancer Research, vol. 79, no. 13_Supplement, American Association for Cancer Research (AACR), 2019, pp. 4900–4900. Crossref, doi:10.1158/1538-7445.am2019-4900.
Freedland S, Lin P-H, Chen EY, Tolstikov V, Chi J-T, Sarangarajan R, Narain NR, Kiebish MA. Abstract 4900: Dynamic metabolic response of prostate cancer patients treated with ADT and low carb diet. Cancer Research. American Association for Cancer Research (AACR); 2019. p. 4900–4900.

Published In

Cancer Research

DOI

EISSN

1538-7445

ISSN

0008-5472

Publication Date

July 1, 2019

Volume

79

Issue

13_Supplement

Start / End Page

4900 / 4900

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis