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Efficacy and safety of cangrelor in patients with peripheral artery disease undergoing percutaneous coronary intervention – Insights from the CHAMPION program

Publication ,  Journal Article
Gutierrez, JA; Harrington, RA; Stone, GW; Steg, PG; Gibson, CM; Hamm, CW; Price, MJ; Lopes, RD; Leonardi, S; Prats, J; Deliargyris, EN ...
Published in: American Heart Journal Plus: Cardiology Research and Practice
September 1, 2021

Background: Peripheral artery disease (PAD) is associated with an increased risk of ischemic events following percutaneous coronary intervention (PCI). More aggressive antiplatelet therapy may mitigate this risk. The present study evaluates the efficacy of cangrelor in patients with PAD undergoing PCI. Methods and results: This is a pooled analysis from the CHAMPION PCI, CHAMPION PLATFORM, AND CHAMPION PHOENIX trials, evaluating cangrelor versus either clopidogrel or placebo in PCI patients. The occurrence of the primary endpoint of death, myocardial infarction, or ischemia-driven revascularization (IDR) was assessed in patients with and without PAD. GUSTO severe bleeding at 48 h was also evaluated. There were 1720 (7%) patients with PAD and 22,802 (93%) without PAD. After adjustment for differences in baseline variables, PAD patients, compared with those without PAD, experienced increased odds of the primary endpoint (OR [95% CI] = 1.27 [0.91, 1.77], P = 0.16) and GUSTO severe bleeding (OR [95% CI] = 3.24 [1.28, 8.21], P = 0.01). In PAD patients, the primary endpoint was 4.7% with cangrelor vs. 7.2% with clopidogrel (OR [95% CI] = 0.64 [0.42,0.96]); in patients without PAD the primary endpoint was 3.5% with cangrelor vs. 4.2% with clopidogrel (OR [95% CI] = 0.83 [0.72,0.95]), P-interaction 0.23. Among patients with or without PAD, there was no significant difference in the rate of GUSTO severe bleeding with cangrelor compared with control, P-interaction 0.86. Conclusions: In a pooled analysis of the CHAMPION studies, PAD was associated with increased rates of ischemic and bleeding complications. Cangrelor reduced the odds of ischemic events, without increasing GUSTO severe bleeding. Clinical trial registration: clinicaltrials.gov identifiers: CHAMPION PCI (NCT00305162), CHAMPION PLATFORM (NCT00385138), CHAMPION PHOENIX (NCT01156571)

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Published In

American Heart Journal Plus: Cardiology Research and Practice

DOI

EISSN

2666-6022

Publication Date

September 1, 2021

Volume

9
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gutierrez, J. A., Harrington, R. A., Stone, G. W., Steg, P. G., Gibson, C. M., Hamm, C. W., … Bhatt, D. L. (2021). Efficacy and safety of cangrelor in patients with peripheral artery disease undergoing percutaneous coronary intervention – Insights from the CHAMPION program. American Heart Journal Plus: Cardiology Research and Practice, 9. https://doi.org/10.1016/j.ahjo.2021.100043
Gutierrez, J. A., R. A. Harrington, G. W. Stone, P. G. Steg, C. M. Gibson, C. W. Hamm, M. J. Price, et al. “Efficacy and safety of cangrelor in patients with peripheral artery disease undergoing percutaneous coronary intervention – Insights from the CHAMPION program.” American Heart Journal Plus: Cardiology Research and Practice 9 (September 1, 2021). https://doi.org/10.1016/j.ahjo.2021.100043.
Gutierrez JA, Harrington RA, Stone GW, Steg PG, Gibson CM, Hamm CW, et al. Efficacy and safety of cangrelor in patients with peripheral artery disease undergoing percutaneous coronary intervention – Insights from the CHAMPION program. American Heart Journal Plus: Cardiology Research and Practice. 2021 Sep 1;9.
Gutierrez, J. A., et al. “Efficacy and safety of cangrelor in patients with peripheral artery disease undergoing percutaneous coronary intervention – Insights from the CHAMPION program.” American Heart Journal Plus: Cardiology Research and Practice, vol. 9, Sept. 2021. Scopus, doi:10.1016/j.ahjo.2021.100043.
Gutierrez JA, Harrington RA, Stone GW, Steg PG, Gibson CM, Hamm CW, Price MJ, Lopes RD, Leonardi S, Prats J, Deliargyris EN, Mahaffey KW, White HD, Bhatt DL. Efficacy and safety of cangrelor in patients with peripheral artery disease undergoing percutaneous coronary intervention – Insights from the CHAMPION program. American Heart Journal Plus: Cardiology Research and Practice. 2021 Sep 1;9.

Published In

American Heart Journal Plus: Cardiology Research and Practice

DOI

EISSN

2666-6022

Publication Date

September 1, 2021

Volume

9