Skip to main content

Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas.

Publication ,  Journal Article
Wood, GE; Graves, LA; Rubin, EM; Reed, DR; Riedel, RF; Strauss, SJ
Published in: Am Soc Clin Oncol Educ Book
May 2023

Bone sarcomas are rare heterogeneous tumors that affect patients of all ages including children, adolescent young adults, and older adults. They include many aggressive subtypes and patient groups with poor outcomes, poor access to clinical trials, and lack of defined standard therapeutic strategies. Conventional chondrosarcoma remains a surgical disease, with no defined role for cytotoxic therapy and no approved targeted systemic therapies. Here, we discuss promising novel targets and strategies undergoing evaluation in clinical trials. Multiagent chemotherapy has greatly improved outcomes for patients with Ewing sarcoma (ES) and osteosarcoma, but management of those with high-risk or recurrent disease remains challenging and controversial. We describe the impact of international collaborative trials, such as the rEECur study, that aim to define optimal treatment strategies for those with recurrent, refractory ES, and evidence for high-dose chemotherapy with stem-cell support. We also discuss current and emerging strategies for other small round cell sarcomas, such as CIC-rearranged, BCOR-rearranged tumors, and the evaluation of emerging novel therapeutics and trial designs that may offer a new paradigm to improve survival in these aggressive tumors with notoriously bad (to the bone) outcomes.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am Soc Clin Oncol Educ Book

DOI

EISSN

1548-8756

Publication Date

May 2023

Volume

43

Start / End Page

e390306

Location

United States

Related Subject Headings

  • Young Adult
  • Sarcoma, Ewing
  • Osteosarcoma
  • Humans
  • Child
  • Bone Neoplasms
  • Aged
  • Adolescent
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wood, G. E., Graves, L. A., Rubin, E. M., Reed, D. R., Riedel, R. F., & Strauss, S. J. (2023). Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas. Am Soc Clin Oncol Educ Book, 43, e390306. https://doi.org/10.1200/EDBK_390306
Wood, Georgina E., Laurie A. Graves, Elyssa M. Rubin, Damon R. Reed, Richard F. Riedel, and Sandra J. Strauss. “Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas.Am Soc Clin Oncol Educ Book 43 (May 2023): e390306. https://doi.org/10.1200/EDBK_390306.
Wood GE, Graves LA, Rubin EM, Reed DR, Riedel RF, Strauss SJ. Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas. Am Soc Clin Oncol Educ Book. 2023 May;43:e390306.
Wood, Georgina E., et al. “Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas.Am Soc Clin Oncol Educ Book, vol. 43, May 2023, p. e390306. Pubmed, doi:10.1200/EDBK_390306.
Wood GE, Graves LA, Rubin EM, Reed DR, Riedel RF, Strauss SJ. Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas. Am Soc Clin Oncol Educ Book. 2023 May;43:e390306.

Published In

Am Soc Clin Oncol Educ Book

DOI

EISSN

1548-8756

Publication Date

May 2023

Volume

43

Start / End Page

e390306

Location

United States

Related Subject Headings

  • Young Adult
  • Sarcoma, Ewing
  • Osteosarcoma
  • Humans
  • Child
  • Bone Neoplasms
  • Aged
  • Adolescent
  • 3211 Oncology and carcinogenesis