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The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study.

Publication ,  Journal Article
Hingorani, S; Gibson, KL; Xie, Y; Wang, Y; Eddy, S; Hartman, J; Sampson, M; Cassol, C; Thomas, D; Gipson, DS; Trachtman, H; Srivastava, T ...
Published in: Pediatric nephrology (Berlin, Germany)
October 2023

In single-center studies, both preterm birth and low birth weight (LBW) are associated with worse outcomes in childhood nephrotic syndrome. Using the Nephrotic Syndrome Study Network (NEPTUNE) observational cohort, we tested the hypothesis that in patients with nephrotic syndrome, hypertension, proteinuria status, and disease progression would be more prevalent and more severe in subjects with LBW and prematurity singly or in combination (LBW/prematurity).Three hundred fifty-nine adults and children with focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD) and available birth history were included. Estimated glomerular filtration rate (eGFR) decline and remission status were primary outcomes, and secondary outcomes were kidney histopathology, kidney gene expression, and urinary biomarkers. Logistic regression was used to identify associations with LBW/prematurity and these outcomes.We did not find an association between LBW/prematurity and remission of proteinuria. However, LBW/prematurity was associated with greater decline in eGFR. This decline in eGFR was partially explained by the association of LBW/prematurity with APOL1 high-risk alleles, but the association remained after adjustment. There were no differences in kidney histopathology or gene expression in the LBW/prematurity group compared to normal birth weight/term birth.LBW and premature babies who develop nephrotic syndrome have a more rapid decline in kidney function. We did not identify clinical or laboratory features that distinguished the groups. Additional studies in larger groups are needed to fully ascertain the effects of (LBW) and prematurity alone or in combination on kidney function in the setting of nephrotic syndrome.

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Published In

Pediatric nephrology (Berlin, Germany)

DOI

EISSN

1432-198X

ISSN

0931-041X

Publication Date

October 2023

Volume

38

Issue

10

Start / End Page

3297 / 3308

Related Subject Headings

  • Urology & Nephrology
  • Proteinuria
  • Premature Birth
  • Neptune
  • Nephrotic Syndrome
  • Infant, Newborn
  • Infant, Low Birth Weight
  • Humans
  • Glomerulosclerosis, Focal Segmental
  • Female
 

Citation

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Hingorani, S., Gibson, K. L., Xie, Y., Wang, Y., Eddy, S., Hartman, J., … NEPTUNE Pediatric Working Group, . (2023). The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study. Pediatric Nephrology (Berlin, Germany), 38(10), 3297–3308. https://doi.org/10.1007/s00467-023-05876-3
Hingorani, Sangeeta, Keisha L. Gibson, Yuping Xie, Yujie Wang, Sean Eddy, John Hartman, Matthew Sampson, et al. “The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study.Pediatric Nephrology (Berlin, Germany) 38, no. 10 (October 2023): 3297–3308. https://doi.org/10.1007/s00467-023-05876-3.
Hingorani S, Gibson KL, Xie Y, Wang Y, Eddy S, Hartman J, et al. The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study. Pediatric nephrology (Berlin, Germany). 2023 Oct;38(10):3297–308.
Hingorani, Sangeeta, et al. “The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study.Pediatric Nephrology (Berlin, Germany), vol. 38, no. 10, Oct. 2023, pp. 3297–308. Epmc, doi:10.1007/s00467-023-05876-3.
Hingorani S, Gibson KL, Xie Y, Wang Y, Eddy S, Hartman J, Sampson M, Cassol C, Thomas D, Gipson DS, Trachtman H, Srivastava T, Reidy K, NEPTUNE Pediatric Working Group. The association of low birthweight and prematurity on outcomes in children and adults with nephrotic syndrome-a NEPTUNE cohort study. Pediatric nephrology (Berlin, Germany). 2023 Oct;38(10):3297–3308.
Journal cover image

Published In

Pediatric nephrology (Berlin, Germany)

DOI

EISSN

1432-198X

ISSN

0931-041X

Publication Date

October 2023

Volume

38

Issue

10

Start / End Page

3297 / 3308

Related Subject Headings

  • Urology & Nephrology
  • Proteinuria
  • Premature Birth
  • Neptune
  • Nephrotic Syndrome
  • Infant, Newborn
  • Infant, Low Birth Weight
  • Humans
  • Glomerulosclerosis, Focal Segmental
  • Female