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A simple reaction-diffusion system as a possible model for the origin of chemotaxis.

Publication ,  Journal Article
Gong, Y; Kiselev, A
Published in: Journal of biological dynamics
December 2023

Chemotaxis is a directed cell movement in response to external chemical stimuli. In this paper, we propose a simple model for the origin of chemotaxis - namely how a directed movement in response to an external chemical signal may occur based on purely reaction-diffusion equations reflecting inner working of the cells. The model is inspired by the well-studied role of the rho-GTPase Cdc42 regulator of cell polarity, in particular in yeast cells. We analyse several versions of the model to better understand its analytic properties and prove global regularity in one and two dimensions. Using computer simulations, we demonstrate that in the framework of this model, at least in certain parameter regimes, the speed of the directed movement appears to be proportional to the size of the gradient of signalling chemical. This coincides with the form of the chemical drift in the most studied mean field model of chemotaxis, the Keller-Segel equation.

Duke Scholars

Published In

Journal of biological dynamics

DOI

EISSN

1751-3766

ISSN

1751-3758

Publication Date

December 2023

Volume

17

Issue

1

Start / End Page

2260833

Related Subject Headings

  • Movement
  • Models, Biological
  • Diffusion
  • Computer Simulation
  • Chemotaxis
  • 49 Mathematical sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

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Gong, Y., & Kiselev, A. (2023). A simple reaction-diffusion system as a possible model for the origin of chemotaxis. Journal of Biological Dynamics, 17(1), 2260833. https://doi.org/10.1080/17513758.2023.2260833
Gong, Yishu, and Alexander Kiselev. “A simple reaction-diffusion system as a possible model for the origin of chemotaxis.Journal of Biological Dynamics 17, no. 1 (December 2023): 2260833. https://doi.org/10.1080/17513758.2023.2260833.
Gong Y, Kiselev A. A simple reaction-diffusion system as a possible model for the origin of chemotaxis. Journal of biological dynamics. 2023 Dec;17(1):2260833.
Gong, Yishu, and Alexander Kiselev. “A simple reaction-diffusion system as a possible model for the origin of chemotaxis.Journal of Biological Dynamics, vol. 17, no. 1, Dec. 2023, p. 2260833. Epmc, doi:10.1080/17513758.2023.2260833.
Gong Y, Kiselev A. A simple reaction-diffusion system as a possible model for the origin of chemotaxis. Journal of biological dynamics. 2023 Dec;17(1):2260833.

Published In

Journal of biological dynamics

DOI

EISSN

1751-3766

ISSN

1751-3758

Publication Date

December 2023

Volume

17

Issue

1

Start / End Page

2260833

Related Subject Headings

  • Movement
  • Models, Biological
  • Diffusion
  • Computer Simulation
  • Chemotaxis
  • 49 Mathematical sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
  • 06 Biological Sciences