Scholars@Duke

Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.

Publication ,  Journal Article
Ajani, JA; D'Amico, TA; Bentrem, DJ; Corvera, CU; Das, P; Enzinger, PC; Enzler, T; Gerdes, H; Gibson, MK; Grierson, P; Gupta, G; Ilson, DH ...
Published in: J Natl Compr Canc Netw
May 2025
Published version (DOI) Link to item

Gastric cancer is the fifth leading cause of cancer-related deaths worldwide. Over 95% of gastric cancers are adenocarcinomas, which are typically classified based on anatomic location and histologic type. Gastric cancer generally carries a poor prognosis because it is often diagnosed at an advanced stage. Systemic therapy can provide palliation, improve survival, and enhance the quality of life in patients with locally advanced or metastatic disease. The implementation of biomarker testing has had a significant impact on clinical practice and patient care. Targeted therapies have demonstrated encouraging results in clinical trials for the treatment of patients with locally advanced or metastatic disease. This selection from the NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer highlights recommendations for biomarker testing and discusses updates for the treatment of advanced disease, including peritoneal carcinoma as only disease and unresectable locally advanced, recurrent, or metastatic disease.

Duke Scholars

Christopher G. Willett
Author Christopher G. Willett Radiation Oncology
Thomas Anthony D'Amico
Author Thomas Anthony D'Amico Surgery, Cardiovascular and Thoracic Surgery

Published In

J Natl Compr Canc Netw

DOI

10.6004/jnccn.2025.0022

EISSN

1540-1413

Publication Date

May 2025

Volume

23

Issue

5

Start / End Page

169 / 191

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Medical Oncology
  • Humans
  • Biomarkers, Tumor
  • 4203 Health services and systems
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ajani, J. A., D’Amico, T. A., Bentrem, D. J., Corvera, C. U., Das, P., Enzinger, P. C., … Stein, M. (2025). Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw, 23(5), 169–191. https://doi.org/10.6004/jnccn.2025.0022
Ajani, Jaffer A., Thomas A. D’Amico, David J. Bentrem, Carlos U. Corvera, Prajnan Das, Peter C. Enzinger, Thomas Enzler, et al. “Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.” J Natl Compr Canc Netw 23, no. 5 (May 2025): 169–91. https://doi.org/10.6004/jnccn.2025.0022.
Ajani JA, D’Amico TA, Bentrem DJ, Corvera CU, Das P, Enzinger PC, et al. Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025 May;23(5):169–91.
Ajani, Jaffer A., et al. “Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.” J Natl Compr Canc Netw, vol. 23, no. 5, May 2025, pp. 169–91. Pubmed, doi:10.6004/jnccn.2025.0022.
Ajani JA, D’Amico TA, Bentrem DJ, Corvera CU, Das P, Enzinger PC, Enzler T, Gerdes H, Gibson MK, Grierson P, Gupta G, Hofstetter WL, Ilson DH, Jalal S, Kim S, Kleinberg LR, Klempner S, Lacy J, Lee B, Licciardi F, Lloyd S, Ly QP, Matsukuma K, McNamara M, Merkow RP, Miller AM, Mukherjee S, Mulcahy MF, Perry KA, Pimiento JM, Reddi DM, Reznik S, Roses RE, Strong VE, Su S, Uboha N, Wainberg ZA, Willett CG, Woo Y, Yoon HH, McMillian NR, Stein M. Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. J Natl Compr Canc Netw. 2025 May;23(5):169–191.

Published In

J Natl Compr Canc Netw

DOI

10.6004/jnccn.2025.0022

EISSN

1540-1413

Publication Date

May 2025

Volume

23

Issue

5

Start / End Page

169 / 191

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Medical Oncology
  • Humans
  • Biomarkers, Tumor
  • 4203 Health services and systems
  • 3211 Oncology and carcinogenesis