RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation
Conferences
Wu, J; Zhou, Y; Burcher, K; Wirthlin, L; Makepeace, J; Noldner, P; Dash, P; Nikiforov, M; Shaz, B; Vuligonda, V; Sanders, M; Kang, Y
Published in: Blood
November 3, 2025
Duke Scholars
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Published In
Blood
DOI
EISSN
1528-0020
ISSN
0006-4971
Publication Date
November 3, 2025
Volume
146
Issue
Supplement 1
Start / End Page
3947 / 3947
Publisher
American Society of Hematology
Related Subject Headings
- Immunology
- 3213 Paediatrics
- 3201 Cardiovascular medicine and haematology
- 3101 Biochemistry and cell biology
Citation
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Wu, J., Zhou, Y., Burcher, K., Wirthlin, L., Makepeace, J., Noldner, P., … Kang, Y. (2025). RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation. In Blood (Vol. 146, pp. 3947–3947). American Society of Hematology. https://doi.org/10.1182/blood-2025-3947
Wu, Jian, Ying Zhou, Kimberly Burcher, Louisa Wirthlin, Jen Makepeace, Pamela Noldner, Pradyot Dash, et al. “RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation.” In Blood, 146:3947–3947. American Society of Hematology, 2025. https://doi.org/10.1182/blood-2025-3947.
Wu J, Zhou Y, Burcher K, Wirthlin L, Makepeace J, Noldner P, et al. RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation. In: Blood. American Society of Hematology; 2025. p. 3947–3947.
Wu, Jian, et al. “RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation.” Blood, vol. 146, no. Supplement 1, American Society of Hematology, 2025, pp. 3947–3947. Crossref, doi:10.1182/blood-2025-3947.
Wu J, Zhou Y, Burcher K, Wirthlin L, Makepeace J, Noldner P, Dash P, Nikiforov M, Shaz B, Vuligonda V, Sanders M, Kang Y. RXR agonist IRX4204 enhances BCMA CAR-T-cell efficacy by suppressing ferroptosis via CHAC1 downregulation. Blood. American Society of Hematology; 2025. p. 3947–3947.
Published In
Blood
DOI
EISSN
1528-0020
ISSN
0006-4971
Publication Date
November 3, 2025
Volume
146
Issue
Supplement 1
Start / End Page
3947 / 3947
Publisher
American Society of Hematology
Related Subject Headings
- Immunology
- 3213 Paediatrics
- 3201 Cardiovascular medicine and haematology
- 3101 Biochemistry and cell biology