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RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy

Conferences
Wu, J; Yan, Z; Burcher, K; Han, Z; Nikiforov, M; Vuligonda, V; Sanders, M; Kang, Y
Published in: Blood
November 3, 2025

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Published In

Blood

DOI

EISSN

1528-0020

ISSN

0006-4971

Publication Date

November 3, 2025

Volume

146

Issue

Supplement 1

Start / End Page

3950 / 3950

Publisher

American Society of Hematology

Related Subject Headings

  • Immunology
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology
 

Citation

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Wu, J., Yan, Z., Burcher, K., Han, Z., Nikiforov, M., Vuligonda, V., … Kang, Y. (2025). RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy. In Blood (Vol. 146, pp. 3950–3950). American Society of Hematology. https://doi.org/10.1182/blood-2025-3950
Wu, Jian, Zhibo Yan, Kimberly Burcher, Zhannan Han, Mikhail Nikiforov, Vidyasagar Vuligonda, Martin Sanders, and Yubin Kang. “RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy.” In Blood, 146:3950–3950. American Society of Hematology, 2025. https://doi.org/10.1182/blood-2025-3950.
Wu J, Yan Z, Burcher K, Han Z, Nikiforov M, Vuligonda V, et al. RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy. In: Blood. American Society of Hematology; 2025. p. 3950–3950.
Wu, Jian, et al. “RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy.” Blood, vol. 146, no. Supplement 1, American Society of Hematology, 2025, pp. 3950–3950. Crossref, doi:10.1182/blood-2025-3950.
Wu J, Yan Z, Burcher K, Han Z, Nikiforov M, Vuligonda V, Sanders M, Kang Y. RXR agonist IRX4204 induces ferroptosis in multiple myeloma via HMOX1/GPX4 axis and enhances lenalidomide efficacy. Blood. American Society of Hematology; 2025. p. 3950–3950.

Published In

Blood

DOI

EISSN

1528-0020

ISSN

0006-4971

Publication Date

November 3, 2025

Volume

146

Issue

Supplement 1

Start / End Page

3950 / 3950

Publisher

American Society of Hematology

Related Subject Headings

  • Immunology
  • 3213 Paediatrics
  • 3201 Cardiovascular medicine and haematology
  • 3101 Biochemistry and cell biology