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Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat.

Publication ,  Journal Article
Chao, NJ; Timmerman, L; McDevitt, HO; Jacob, CO
Published in: Immunogenetics
1989

The BB or BB/Worcester (BB/W) rat is widely recognized as a model for human insulin-dependent diabetes mellitus (IDDM). Of at least three genes implicated in genetic susceptibility to IDDM in this strain, one is clearly linked to the major histocompatibility complex (MHC). In an attempt to define the diabetogenic gene(s) linked to the MHC of the BB rat, cDNA clones encoding the class II MHC gene products of the BB diabetes-prone and diabetes-resistant sublines have been isolated and sequenced. For comparison, the beta 1 domain of class II genes of the Lewis rat (RT1L) were sequenced. Analysis of the sequence data reveals that the first domain of RT1.D beta and RT1.B beta chain of the BB rat are different from other rat or mouse class II sequences. However, these sequences were identical in both the BB diabetes-prone and BB diabetes-resistant sublines. The significance of these findings is discussed in relation to MHC class II sequence data in IDDM patients and in the nonobese diabetic (NOD) mouse strain.

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Published In

Immunogenetics

DOI

ISSN

0093-7711

Publication Date

1989

Volume

29

Issue

4

Start / End Page

231 / 234

Location

United States

Related Subject Headings

  • Rats, Mutant Strains
  • Rats, Inbred Lew
  • Rats
  • Molecular Sequence Data
  • Immunology
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Experimental
  • DNA
  • Base Sequence
  • Animals
 

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ICMJE
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Chao, N. J., Timmerman, L., McDevitt, H. O., & Jacob, C. O. (1989). Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. Immunogenetics, 29(4), 231–234. https://doi.org/10.1007/BF00717906
Chao, N. J., L. Timmerman, H. O. McDevitt, and C. O. Jacob. “Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat.Immunogenetics 29, no. 4 (1989): 231–34. https://doi.org/10.1007/BF00717906.
Chao NJ, Timmerman L, McDevitt HO, Jacob CO. Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. Immunogenetics. 1989;29(4):231–4.
Chao, N. J., et al. “Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat.Immunogenetics, vol. 29, no. 4, 1989, pp. 231–34. Pubmed, doi:10.1007/BF00717906.
Chao NJ, Timmerman L, McDevitt HO, Jacob CO. Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. Immunogenetics. 1989;29(4):231–234.
Journal cover image

Published In

Immunogenetics

DOI

ISSN

0093-7711

Publication Date

1989

Volume

29

Issue

4

Start / End Page

231 / 234

Location

United States

Related Subject Headings

  • Rats, Mutant Strains
  • Rats, Inbred Lew
  • Rats
  • Molecular Sequence Data
  • Immunology
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Experimental
  • DNA
  • Base Sequence
  • Animals