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The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).

Publication ,  Journal Article
Kraan, MC; Patel, DD; Haringman, JJ; Smith, MD; Weedon, H; Ahern, MJ; Breedveld, FC; Tak, PP
Published in: Arthritis Res
2001

Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.

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Published In

Arthritis Res

DOI

ISSN

1465-9905

Publication Date

2001

Volume

3

Issue

1

Start / End Page

65 / 71

Location

England

Related Subject Headings

  • Synovial Membrane
  • Knee Joint
  • Interleukin-8
  • In Situ Hybridization
  • Immunohistochemistry
  • Humans
  • Enzyme-Linked Immunosorbent Assay
  • Arthritis, Rheumatoid
  • Arthritis & Rheumatology
  • 3204 Immunology
 

Citation

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Kraan, M. C., Patel, D. D., Haringman, J. J., Smith, M. D., Weedon, H., Ahern, M. J., … Tak, P. P. (2001). The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8). Arthritis Res, 3(1), 65–71. https://doi.org/10.1186/ar141
Kraan, M. C., D. D. Patel, J. J. Haringman, M. D. Smith, H. Weedon, M. J. Ahern, F. C. Breedveld, and P. P. Tak. “The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).Arthritis Res 3, no. 1 (2001): 65–71. https://doi.org/10.1186/ar141.
Kraan MC, Patel DD, Haringman JJ, Smith MD, Weedon H, Ahern MJ, et al. The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8). Arthritis Res. 2001;3(1):65–71.
Kraan, M. C., et al. “The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).Arthritis Res, vol. 3, no. 1, 2001, pp. 65–71. Pubmed, doi:10.1186/ar141.
Kraan MC, Patel DD, Haringman JJ, Smith MD, Weedon H, Ahern MJ, Breedveld FC, Tak PP. The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8). Arthritis Res. 2001;3(1):65–71.

Published In

Arthritis Res

DOI

ISSN

1465-9905

Publication Date

2001

Volume

3

Issue

1

Start / End Page

65 / 71

Location

England

Related Subject Headings

  • Synovial Membrane
  • Knee Joint
  • Interleukin-8
  • In Situ Hybridization
  • Immunohistochemistry
  • Humans
  • Enzyme-Linked Immunosorbent Assay
  • Arthritis, Rheumatoid
  • Arthritis & Rheumatology
  • 3204 Immunology