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Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease.

Publication ,  Journal Article
Tenore, A; Berman, WF; Parks, JS; Bongiovanni, AM
Published in: J Clin Endocrinol Metab
April 1977

Patients with inflammatory bowel disease (IBD) manifest growth failure which may antecede abdominal symptoms by some years. Eight of ten children with documented IBD had records of decreasing growth velocities. Investigation of growth hormone reserves showed excessive rather than impaired responses. Mean basal GH level was 6.2 +/- 0.75 (SEM) ng/ml. During sleep, the mean GH level rose to 26.0 +/- 4.7 ng/ml and following propranolol-glucagon stimulation, to 46.0 +/- 4.5 ng/ml. All values were significantly higher than levels obtained in a control population of 25 children investigated for short stature who were not GH deficient. The mean peak GH response following insulin in the IBD group (10.8 +/- 3.8 ng/ml), however, did not differ from the mean peak response in the control group (13.5 +/- 3.3 ng/ml). Growth failure in patients with IBD is not the result of GH deficiency and is not an irreversible phenomenon. On the contrary, judicious use of glucocorticoids aimed at the control of the disease usually produces compensatory growth acceleration ("catch-up growth").

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Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

April 1977

Volume

44

Issue

4

Start / End Page

622 / 628

Location

United States

Related Subject Headings

  • Sulfasalazine
  • Sheep
  • Propranolol
  • Prednisone
  • Male
  • Insulin
  • Humans
  • Growth Hormone
  • Glucagon
  • Female
 

Citation

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Tenore, A., Berman, W. F., Parks, J. S., & Bongiovanni, A. M. (1977). Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease. J Clin Endocrinol Metab, 44(4), 622–628. https://doi.org/10.1210/jcem-44-4-622
Tenore, A., W. F. Berman, J. S. Parks, and A. M. Bongiovanni. “Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease.J Clin Endocrinol Metab 44, no. 4 (April 1977): 622–28. https://doi.org/10.1210/jcem-44-4-622.
Tenore A, Berman WF, Parks JS, Bongiovanni AM. Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease. J Clin Endocrinol Metab. 1977 Apr;44(4):622–8.
Tenore, A., et al. “Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease.J Clin Endocrinol Metab, vol. 44, no. 4, Apr. 1977, pp. 622–28. Pubmed, doi:10.1210/jcem-44-4-622.
Tenore A, Berman WF, Parks JS, Bongiovanni AM. Basal and stimulated serum growth hormone concentrations in inflammatory bowel disease. J Clin Endocrinol Metab. 1977 Apr;44(4):622–628.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

April 1977

Volume

44

Issue

4

Start / End Page

622 / 628

Location

United States

Related Subject Headings

  • Sulfasalazine
  • Sheep
  • Propranolol
  • Prednisone
  • Male
  • Insulin
  • Humans
  • Growth Hormone
  • Glucagon
  • Female