Skip to main content
Journal cover image

Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse.

Publication ,  Journal Article
Giacchino, JL; Somjen, GG; Frush, DP; McNamara, JO
Published in: Exp Neurol
December 1984

Kindling is an animal model of epilepsy which involves a permanently enhanced neuronal response to an electrical stimulus. It has been proposed that long-term potentiation (LTP) of excitatory synaptic transmission is the cellular basis of kindling. Therefore, LTP was examined in the monosynaptic projections from the lateral entorhinal cortex (LEC) to dentate granule cells (DG) in unrestrained, unanesthetized rats kindled via the LEC. Population excitatory postsynaptic potentials (pEPSPs) were recorded from the granule cells before, during, and after kindling of the LEC. Controls were unkindled rats recorded during the same time period as the experimental rats. No consistent changes were found in plateau pEPSP amplitudes or initial slopes although kindling via the LEC proceeded through the typical stages. There was also no significant change in the stimulus intensity needed to elicit a 50% maximal or "plateau" pEPSP. Thus, whereas kindling was indeed established by stimulation of the LEC, there was no evidence of LTP detected in the granule cell response either during the development or after completion of kindling. Either LTP does not underlie the mechanism of kindling via this pathway or it occurs in different brain regions receiving LEC input.

Duke Scholars

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

December 1984

Volume

86

Issue

3

Start / End Page

483 / 492

Location

United States

Related Subject Headings

  • Synapses
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Limbic System
  • Kindling, Neurologic
  • Evoked Potentials
  • Electric Stimulation
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Giacchino, J. L., Somjen, G. G., Frush, D. P., & McNamara, J. O. (1984). Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse. Exp Neurol, 86(3), 483–492. https://doi.org/10.1016/0014-4886(84)90083-9
Giacchino, J. L., G. G. Somjen, D. P. Frush, and J. O. McNamara. “Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse.Exp Neurol 86, no. 3 (December 1984): 483–92. https://doi.org/10.1016/0014-4886(84)90083-9.
Giacchino JL, Somjen GG, Frush DP, McNamara JO. Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse. Exp Neurol. 1984 Dec;86(3):483–92.
Giacchino, J. L., et al. “Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse.Exp Neurol, vol. 86, no. 3, Dec. 1984, pp. 483–92. Pubmed, doi:10.1016/0014-4886(84)90083-9.
Giacchino JL, Somjen GG, Frush DP, McNamara JO. Lateral entorhinal cortical kindling can be established without potentiation of the entorhinal-granule cell synapse. Exp Neurol. 1984 Dec;86(3):483–492.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

December 1984

Volume

86

Issue

3

Start / End Page

483 / 492

Location

United States

Related Subject Headings

  • Synapses
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Male
  • Limbic System
  • Kindling, Neurologic
  • Evoked Potentials
  • Electric Stimulation
  • Animals