Skip to main content
Journal cover image

Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery.

Publication ,  Journal Article
Frush, DP; Babcock, DS; White, KS; Barr, LL
Published in: Ultrasound Med Biol
1995

In vivo evaluation of Doppler contrast agent (DCA) enhancement has been principally qualitative. To quantitate the enhancement of the Doppler signal by perflubron emulsion, an investigational DCA, the audio-Doppler signal from the rabbit carotid artery was recorded during 0.5-ml/kg incremental doses to a total dose of 2.5 ml/kg. A representation of the recorded signal intensity, the Doppler power spectrum (DPS), was determined using a personal computer and commercially available software package. The dose related enhancement from perflubron emulsion was linear (r = 0.986, p = 0.0124) with a 710% (8.5 dB) overall enhancement at 2.5 ml/kg (p = 0.0001). Significant differences in enhancement could be detected with doses as low as 1.0 ml/kg and compared favorably with observer assessment of dose-related enhancement. This relatively simple method of computer analysis can quantify in vivo Doppler signal intensity and enhancement by perflubron emulsion and may enable quantitative comparisons between different DCAs.

Duke Scholars

Published In

Ultrasound Med Biol

DOI

ISSN

0301-5629

Publication Date

1995

Volume

21

Issue

1

Start / End Page

41 / 47

Location

England

Related Subject Headings

  • Ultrasonography, Doppler, Duplex
  • Ultrasonography, Doppler, Color
  • Ultrasonography, Doppler
  • Software
  • Signal Processing, Computer-Assisted
  • Rabbits
  • Observer Variation
  • Male
  • Linear Models
  • Injections, Intravenous
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Frush, D. P., Babcock, D. S., White, K. S., & Barr, L. L. (1995). Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery. Ultrasound Med Biol, 21(1), 41–47. https://doi.org/10.1016/0301-5629(94)00097-2
Frush, D. P., D. S. Babcock, K. S. White, and L. L. Barr. “Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery.Ultrasound Med Biol 21, no. 1 (1995): 41–47. https://doi.org/10.1016/0301-5629(94)00097-2.
Frush DP, Babcock DS, White KS, Barr LL. Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery. Ultrasound Med Biol. 1995;21(1):41–7.
Frush, D. P., et al. “Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery.Ultrasound Med Biol, vol. 21, no. 1, 1995, pp. 41–47. Pubmed, doi:10.1016/0301-5629(94)00097-2.
Frush DP, Babcock DS, White KS, Barr LL. Quantification of intravenous contrast-enhanced Doppler power spectrum in the rabbit carotid artery. Ultrasound Med Biol. 1995;21(1):41–47.
Journal cover image

Published In

Ultrasound Med Biol

DOI

ISSN

0301-5629

Publication Date

1995

Volume

21

Issue

1

Start / End Page

41 / 47

Location

England

Related Subject Headings

  • Ultrasonography, Doppler, Duplex
  • Ultrasonography, Doppler, Color
  • Ultrasonography, Doppler
  • Software
  • Signal Processing, Computer-Assisted
  • Rabbits
  • Observer Variation
  • Male
  • Linear Models
  • Injections, Intravenous