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Magnetic resonance findings in patients with early-onset Alzheimer's disease.

Publication ,  Journal Article
McDonald, WM; Krishnan, KR; Doraiswamy, PM; Figiel, GS; Husain, MM; Boyko, OB; Heyman, A
Published in: Biol Psychiatry
April 15, 1991

The magnetic resonance scans of 22 patients with early-onset Alzheimer's disease (AD) were compared to 16 age-matched neurologically normal controls for the presence of white matter subcortical hyperintensities (SCH) and periventricular hyperintensities (PVH). Patients with AD were significantly more likely to have evidence of PVH (p less than 0.01) than age-matched controls. There was no significant difference between the two groups in either the frequency of SCH or the size of the largest lesion. Within the AD group, there was no difference demonstrated in the location of the SCH, either in the anterior-posterior plane or between the two hemispheres. Patients with AD more frequently demonstrated ventriculomegaly (p less than 0.001) and sulcal widening (p less than 0.05) compared with controls. This study suggests that the SCH seen in early-onset AD patients on MRI are related more to the aging process than to the AD process and that the increased frequency of PVH may have a relationship to the disease process.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

April 15, 1991

Volume

29

Issue

8

Start / End Page

799 / 810

Location

United States

Related Subject Headings

  • Psychiatry
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cerebral Ventricles
  • Cerebral Cortex
  • Brain
 

Citation

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MLA
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McDonald, W. M., Krishnan, K. R., Doraiswamy, P. M., Figiel, G. S., Husain, M. M., Boyko, O. B., & Heyman, A. (1991). Magnetic resonance findings in patients with early-onset Alzheimer's disease. Biol Psychiatry, 29(8), 799–810. https://doi.org/10.1016/0006-3223(91)90199-v
McDonald, W. M., K. R. Krishnan, P. M. Doraiswamy, G. S. Figiel, M. M. Husain, O. B. Boyko, and A. Heyman. “Magnetic resonance findings in patients with early-onset Alzheimer's disease.Biol Psychiatry 29, no. 8 (April 15, 1991): 799–810. https://doi.org/10.1016/0006-3223(91)90199-v.
McDonald WM, Krishnan KR, Doraiswamy PM, Figiel GS, Husain MM, Boyko OB, et al. Magnetic resonance findings in patients with early-onset Alzheimer's disease. Biol Psychiatry. 1991 Apr 15;29(8):799–810.
McDonald, W. M., et al. “Magnetic resonance findings in patients with early-onset Alzheimer's disease.Biol Psychiatry, vol. 29, no. 8, Apr. 1991, pp. 799–810. Pubmed, doi:10.1016/0006-3223(91)90199-v.
McDonald WM, Krishnan KR, Doraiswamy PM, Figiel GS, Husain MM, Boyko OB, Heyman A. Magnetic resonance findings in patients with early-onset Alzheimer's disease. Biol Psychiatry. 1991 Apr 15;29(8):799–810.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

April 15, 1991

Volume

29

Issue

8

Start / End Page

799 / 810

Location

United States

Related Subject Headings

  • Psychiatry
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Cerebral Ventricles
  • Cerebral Cortex
  • Brain