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Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.

Publication ,  Journal Article
Furuta, Y; Piston, DW; Hogan, BL
Published in: Development
June 1997

Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of developmental processes, but their functions during early vertebrate brain development are largely unknown. To investigate this problem, we have compared by in situ hybridization the expression of five Bmp genes belonging to the Drosophila Decapentaplegic (Bmp2 and Bmp4) and 60A subgroups (Bmp5, Bmp6 and Bmp7). Striking co-expression of these Bmps is observed within the dorsomedial telencephalon, coincident with a future site of choroid plexus development. Bmp co-expression overlaps that of Msx1 and Hfh4, and is complementary to that of Bf1. The domain of Bmp co-expression is also associated with limited growth of the neuroectoderm, as revealed by morphological observation, reduced cell proliferation, and increased local programmed cell death. In vitro experiments using explants from the embryonic lateral telencephalic neuroectoderm reveal that exogenous BMP proteins (BMP4 and BMP2) induce expression of Msx1 and inhibit Bf1 expression, a finding consistent with their specific expression patterns in vivo. Moreover, BMP proteins locally inhibit cell proliferation and increase apoptosis in the explants. These results provide evidence that BMPs function during regional morphogenesis of the dorsal telencephalon by regulating specific gene expression, cell proliferation and local cell death.

Duke Scholars

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Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 1997

Volume

124

Issue

11

Start / End Page

2203 / 2212

Location

England

Related Subject Headings

  • Transcription Factors
  • RNA, Messenger
  • Prosencephalon
  • Mice, Inbred ICR
  • Mice
  • MSX1 Transcription Factor
  • In Situ Hybridization
  • Image Processing, Computer-Assisted
  • Homeodomain Proteins
  • Gene Expression Regulation, Developmental
 

Citation

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Furuta, Y., Piston, D. W., & Hogan, B. L. (1997). Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development, 124(11), 2203–2212. https://doi.org/10.1242/dev.124.11.2203
Furuta, Y., D. W. Piston, and B. L. Hogan. “Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.Development 124, no. 11 (June 1997): 2203–12. https://doi.org/10.1242/dev.124.11.2203.
Furuta Y, Piston DW, Hogan BL. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 1997 Jun;124(11):2203–12.
Furuta, Y., et al. “Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development.Development, vol. 124, no. 11, June 1997, pp. 2203–12. Pubmed, doi:10.1242/dev.124.11.2203.
Furuta Y, Piston DW, Hogan BL. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 1997 Jun;124(11):2203–2212.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 1997

Volume

124

Issue

11

Start / End Page

2203 / 2212

Location

England

Related Subject Headings

  • Transcription Factors
  • RNA, Messenger
  • Prosencephalon
  • Mice, Inbred ICR
  • Mice
  • MSX1 Transcription Factor
  • In Situ Hybridization
  • Image Processing, Computer-Assisted
  • Homeodomain Proteins
  • Gene Expression Regulation, Developmental