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Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

Publication ,  Journal Article
Lyons, K; Graycar, JL; Lee, A; Hashmi, S; Lindquist, PB; Chen, EY; Hogan, BL; Derynck, R
Published in: Proc Natl Acad Sci U S A
June 1989
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The transforming growth factor beta (TGF-beta)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-beta superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.

Duke Scholars

Brigid L. M. Hogan
Author Brigid L. M. Hogan Cell Biology
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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.86.12.4554

ISSN

0027-8424

Publication Date

June 1989

Volume

86

Issue

12

Start / End Page

4554 / 4558

Location

United States

Related Subject Headings

  • Xenopus
  • Transforming Growth Factors
  • Species Specificity
  • Sequence Homology, Nucleic Acid
  • Organ Specificity
  • Multigene Family
  • Molecular Sequence Data
  • Mice, Inbred ICR
  • Mice
  • Genes
 

Citation

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Lyons, K., Graycar, J. L., Lee, A., Hashmi, S., Lindquist, P. B., Chen, E. Y., … Derynck, R. (1989). Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A, 86(12), 4554–4558. https://doi.org/10.1073/pnas.86.12.4554
Lyons, K., J. L. Graycar, A. Lee, S. Hashmi, P. B. Lindquist, E. Y. Chen, B. L. Hogan, and R. Derynck. “Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.” Proc Natl Acad Sci U S A 86, no. 12 (June 1989): 4554–58. https://doi.org/10.1073/pnas.86.12.4554.
Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, et al. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554–8.
Lyons, K., et al. “Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.” Proc Natl Acad Sci U S A, vol. 86, no. 12, June 1989, pp. 4554–58. Pubmed, doi:10.1073/pnas.86.12.4554.
Lyons K, Graycar JL, Lee A, Hashmi S, Lindquist PB, Chen EY, Hogan BL, Derynck R. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554–4558.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.86.12.4554

ISSN

0027-8424

Publication Date

June 1989

Volume

86

Issue

12

Start / End Page

4554 / 4558

Location

United States

Related Subject Headings

  • Xenopus
  • Transforming Growth Factors
  • Species Specificity
  • Sequence Homology, Nucleic Acid
  • Organ Specificity
  • Multigene Family
  • Molecular Sequence Data
  • Mice, Inbred ICR
  • Mice
  • Genes