Skip to main content
Journal cover image

Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors.

Publication ,  Journal Article
Topczewska, JM; Topczewski, J; Solnica-Krezel, L; Hogan, BL
Published in: Mech Dev
February 2001

Mouse Foxc1 (previously Mf1) is a member of the conserved forkhead/winged helix transcription factor gene family. It is expressed in many mesodermal tissues including paraxial mesoderm of the trunk and head, prechondrogenic mesenchyme, branchial arches and developing kidney. Homozygous mutants die perinatally with hydrocephalus and skeletal, cardiovascular, ocular and genitourinary defects. Here, we report the cloning and expression of two zebrafish foxc1 homologues, foxc1a and foxc1b. During gastrulation and somitogenesis both genes have similar expression patterns in the hypoblast, paraxial and presomitic mesoderm, somites and trunk adaxial cells. Expression in the somites is downregulated as they differentiate, but is maintained in the sclerotome. Later, some differences in expression pattern emerge. For example, only foxc1a transcripts are detected in the pronephros primodia and in the head mesoderm around the eyes, while only foxc1b is expressed in the pharyngeal arches and pectoral fins. Early expression of foxc1a in the paraxial mesoderm is modified in chordino, swirl, somitabun, and spadetail mutants.

Duke Scholars

Published In

Mech Dev

DOI

ISSN

0925-4773

Publication Date

February 2001

Volume

100

Issue

2

Start / End Page

343 / 347

Location

Ireland

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Transcription, Genetic
  • Transcription Factors
  • Tissue Distribution
  • Time Factors
  • Somites
  • Sequence Homology, Amino Acid
  • RNA, Messenger
  • Mutation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Topczewska, J. M., Topczewski, J., Solnica-Krezel, L., & Hogan, B. L. (2001). Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mech Dev, 100(2), 343–347. https://doi.org/10.1016/s0925-4773(00)00534-7
Topczewska, J. M., J. Topczewski, L. Solnica-Krezel, and B. L. Hogan. “Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors.Mech Dev 100, no. 2 (February 2001): 343–47. https://doi.org/10.1016/s0925-4773(00)00534-7.
Topczewska JM, Topczewski J, Solnica-Krezel L, Hogan BL. Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mech Dev. 2001 Feb;100(2):343–7.
Topczewska, J. M., et al. “Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors.Mech Dev, vol. 100, no. 2, Feb. 2001, pp. 343–47. Pubmed, doi:10.1016/s0925-4773(00)00534-7.
Topczewska JM, Topczewski J, Solnica-Krezel L, Hogan BL. Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mech Dev. 2001 Feb;100(2):343–347.
Journal cover image

Published In

Mech Dev

DOI

ISSN

0925-4773

Publication Date

February 2001

Volume

100

Issue

2

Start / End Page

343 / 347

Location

Ireland

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Transcription, Genetic
  • Transcription Factors
  • Tissue Distribution
  • Time Factors
  • Somites
  • Sequence Homology, Amino Acid
  • RNA, Messenger
  • Mutation