The murine Hox-2 cluster of homeo box containing genes maps distal on chromosome 11 near the tail-short (Ts) locus.
Two probes derived from a mouse recombinant lambda-clone (H24.1), that contains a sequence closely homologous to the Drosophila antennapedia homeo box, were mapped to mouse chromosome (MMU) 11 by filter hybridization of somatic cell hybrid DNA. This sequence is highly homologous to a human homeo box gene (HOX2) and appears to represent one of the two genes in the Hox-2 cluster previously assigned to MMU 11. To regionally map the Hox-2 cluster, we have carried out in situ hybridization of the two H24.1 probes and of an independently isolated Hox-2 probe. The autoradiographic silver grain distributions were similar in all three experiments with a peak over band 11D. This region contains the locus for the tail-short (Ts) mutation which causes skeletal abnormalities in heterozygotes and early embryonic death in homozygotes.
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- Nucleic Acid Hybridization
- Mice
- Karyotyping
- Hybrid Cells
- Genetics & Heredity
- Genes, Homeobox
- DNA Restriction Enzymes
- Cricetulus
- Cricetinae
- Chromosome Mapping
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Nucleic Acid Hybridization
- Mice
- Karyotyping
- Hybrid Cells
- Genetics & Heredity
- Genes, Homeobox
- DNA Restriction Enzymes
- Cricetulus
- Cricetinae
- Chromosome Mapping