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Angiotensin-II-receptors: new targets for antihypertensive therapy.

Publication ,  Journal Article
Oliverio, MI; Coffman, TM
Published in: Clin Cardiol
January 1997

The renin-angiotensin system regulates blood pressure and sodium homeostasis through a series of coordinated substrate-enzyme interactions. These interactions result in the production of angiotensin II (AII), which exerts a number of diverse biologic effects mediated through AII cell-surface receptors. Dysregulation of this system is implicated in the pathogenesis of various forms of hypertension. Traditional therapy for hypertension has included angiotensin-converting enzyme inhibitors, which block the production of AII. However, a new class of drugs, AT1-receptor blockers, now offers a number of benefits by specifically blocking the effects of AII at its physiologically relevant receptor.

Duke Scholars

Published In

Clin Cardiol

DOI

ISSN

0160-9289

Publication Date

January 1997

Volume

20

Issue

1

Start / End Page

3 / 6

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Receptors, Angiotensin
  • Hypertension
  • Humans
  • Cardiovascular System & Hematology
  • Blood Pressure
  • Antihypertensive Agents
  • Angiotensin Receptor Antagonists
  • Angiotensin II
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Oliverio, M. I., & Coffman, T. M. (1997). Angiotensin-II-receptors: new targets for antihypertensive therapy. Clin Cardiol, 20(1), 3–6. https://doi.org/10.1002/clc.4960200103
Oliverio, M. I., and T. M. Coffman. “Angiotensin-II-receptors: new targets for antihypertensive therapy.Clin Cardiol 20, no. 1 (January 1997): 3–6. https://doi.org/10.1002/clc.4960200103.
Oliverio MI, Coffman TM. Angiotensin-II-receptors: new targets for antihypertensive therapy. Clin Cardiol. 1997 Jan;20(1):3–6.
Oliverio, M. I., and T. M. Coffman. “Angiotensin-II-receptors: new targets for antihypertensive therapy.Clin Cardiol, vol. 20, no. 1, Jan. 1997, pp. 3–6. Pubmed, doi:10.1002/clc.4960200103.
Oliverio MI, Coffman TM. Angiotensin-II-receptors: new targets for antihypertensive therapy. Clin Cardiol. 1997 Jan;20(1):3–6.

Published In

Clin Cardiol

DOI

ISSN

0160-9289

Publication Date

January 1997

Volume

20

Issue

1

Start / End Page

3 / 6

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Receptors, Angiotensin
  • Hypertension
  • Humans
  • Cardiovascular System & Hematology
  • Blood Pressure
  • Antihypertensive Agents
  • Angiotensin Receptor Antagonists
  • Angiotensin II
  • 3201 Cardiovascular medicine and haematology