Skip to main content

Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.

Publication ,  Journal Article
Hamawaki, M; Coffman, TM; Lashus, A; Koide, M; Zile, MR; Oliverio, MI; DeFreyte, G; Cooper, G; Carabello, BA
Published in: The American journal of physiology
March 1998

Mechanisms controlling cardiac growth are under intense investigation. Among these, the renin-angiotensin system has received great interest. In the current study, we tested the hypothesis that the renin-angiotensin system was not an obligate factor in cardiac hypertrophy. We examined the left ventricular hypertrophic response to a pressure overload in mice devoid of the AT1A receptor, the putative major effector of the growth response of the renin-angiotensin system. Aortic banding produced similar transband gradients in wild-type and AT1A knockout mice. The left ventricular mass-to-body weight ratio increased from 3.44 +/- 0.08 to 5.62 +/- 0.25 in wild-type ascending aortic-banded mice. The response in the knockout mice was not different (from 2.97 +/- 0.13 to 5.24 +/- 0.37). We conclude that the magnitude of cardiac hypertrophy is not affected by the absence of the AT1A receptor and its signaling pathway and that this component of the renin-angiotensin system is not necessary in cardiac hypertrophy.

Duke Scholars

Published In

The American journal of physiology

ISSN

0002-9513

Publication Date

March 1998

Volume

274

Issue

3 Pt 2

Start / End Page

H868 / H873

Location

united states

Related Subject Headings

  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hamawaki, M., Coffman, T. M., Lashus, A., Koide, M., Zile, M. R., Oliverio, M. I., … Carabello, B. A. (1998). Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. The American Journal of Physiology, 274(3 Pt 2), H868–H873.
Hamawaki, M., T. M. Coffman, A. Lashus, M. Koide, M. R. Zile, M. I. Oliverio, G. DeFreyte, G. Cooper, and B. A. Carabello. “Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.The American Journal of Physiology 274, no. 3 Pt 2 (March 1998): H868–73.
Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, et al. Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. The American journal of physiology. 1998 Mar;274(3 Pt 2):H868–73.
Hamawaki, M., et al. “Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.The American Journal of Physiology, vol. 274, no. 3 Pt 2, Mar. 1998, pp. H868–73.
Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, DeFreyte G, Cooper G, Carabello BA. Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. The American journal of physiology. 1998 Mar;274(3 Pt 2):H868–H873.

Published In

The American journal of physiology

ISSN

0002-9513

Publication Date

March 1998

Volume

274

Issue

3 Pt 2

Start / End Page

H868 / H873

Location

united states

Related Subject Headings

  • Cardiovascular System & Hematology