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Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists.

Publication ,  Journal Article
Madan, M; Blankenship, JC; Berkowitz, SD
Published in: Curr Opin Hematol
September 1999

Platelet glycoprotein (GP) IIb/IIIa receptor antagonists are being used with increasing frequency in the settings of percutaneous coronary interventions and acute ischemic syndromes. The development of bleeding complications following GPIIb/IIIa blockade represents a significant limitation to its effectiveness. Baseline characteristics predictive of future bleeding events in patients receiving platelet GPIIb/IIIa receptor antagonist include older age, low body weight, evolving myocardial infarction, and female sex. In patients undergoing percutaneous coronary interventions with adjunctive GPIIb/IIIa inhibition, the risk of bleeding, particularly from the femoral vascular access site, may be reduced through the use of low-dose, weight-adjusted heparin (70 U/kg), avoidance of postprocedural heparin, and early vascular sheath removal. Strategies to reduce the incidence of bleeding complications in patients receiving GPIIb/IIIa inhibitors are proposed in this article.

Duke Scholars

Published In

Curr Opin Hematol

DOI

ISSN

1065-6251

Publication Date

September 1999

Volume

6

Issue

5

Start / End Page

334 / 341

Location

United States

Related Subject Headings

  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Aggregation Inhibitors
  • Immunology
  • Humans
  • Hemorrhage
  • Coronary Disease
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Madan, M., Blankenship, J. C., & Berkowitz, S. D. (1999). Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists. Curr Opin Hematol, 6(5), 334–341. https://doi.org/10.1097/00062752-199909000-00011
Madan, M., J. C. Blankenship, and S. D. Berkowitz. “Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists.Curr Opin Hematol 6, no. 5 (September 1999): 334–41. https://doi.org/10.1097/00062752-199909000-00011.
Madan M, Blankenship JC, Berkowitz SD. Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists. Curr Opin Hematol. 1999 Sep;6(5):334–41.
Madan, M., et al. “Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists.Curr Opin Hematol, vol. 6, no. 5, Sept. 1999, pp. 334–41. Pubmed, doi:10.1097/00062752-199909000-00011.
Madan M, Blankenship JC, Berkowitz SD. Bleeding complications with platelet glycoprotein IIb/IIIa receptor antagonists. Curr Opin Hematol. 1999 Sep;6(5):334–341.

Published In

Curr Opin Hematol

DOI

ISSN

1065-6251

Publication Date

September 1999

Volume

6

Issue

5

Start / End Page

334 / 341

Location

United States

Related Subject Headings

  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Platelet Aggregation Inhibitors
  • Immunology
  • Humans
  • Hemorrhage
  • Coronary Disease
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology