Skip to main content
Journal cover image

Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole.

Publication ,  Journal Article
Johnston, RB; Wilfert, CM; Buckley, RH; Webb, LS; DcChatelet, LR; McCall, CE
Published in: Lancet
April 12, 1975

The decrease in the frequency and severity of bacterial infections in four of five children with chronic granulomatous disease (C.G.D.) on long-term sulphonamide therapy was out of proportion to demonstrable direct antibacterial effects of the drug. In an attempt to determine the mechanism for this apparent protective effect, the killing of sulphisoxazole-resistant Escherichia coli and Staphylococcus aureus by leucocytes from five patients with C.G.D. was studied in the presence or absence of 5-50 mug. per ml. sulphisoxazole. With leucocytes from all five patients there was a modest but reproducible enhancement of bactericidal activity in the presence of the sulphonamide. Studies of phagocytosis-associated oxidative metabolism in patients' cell have not revealed a metabolic basis for improved killing.

Duke Scholars

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

April 12, 1975

Volume

1

Issue

7911

Start / End Page

824 / 827

Location

England

Related Subject Headings

  • Sulfisoxazole
  • Phagocytosis
  • Phagocytes
  • Male
  • Leukocytes
  • Infections
  • Infant
  • Humans
  • Granulomatous Disease, Chronic
  • General & Internal Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Johnston, R. B., Wilfert, C. M., Buckley, R. H., Webb, L. S., DcChatelet, L. R., & McCall, C. E. (1975). Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. Lancet, 1(7911), 824–827. https://doi.org/10.1016/s0140-6736(75)93002-0
Johnston, R. B., C. M. Wilfert, R. H. Buckley, L. S. Webb, L. R. DcChatelet, and C. E. McCall. “Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole.Lancet 1, no. 7911 (April 12, 1975): 824–27. https://doi.org/10.1016/s0140-6736(75)93002-0.
Johnston RB, Wilfert CM, Buckley RH, Webb LS, DcChatelet LR, McCall CE. Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. Lancet. 1975 Apr 12;1(7911):824–7.
Johnston, R. B., et al. “Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole.Lancet, vol. 1, no. 7911, Apr. 1975, pp. 824–27. Pubmed, doi:10.1016/s0140-6736(75)93002-0.
Johnston RB, Wilfert CM, Buckley RH, Webb LS, DcChatelet LR, McCall CE. Enhanced bactericidal activity of phagocytes from patients with chronic granulomatous disease in the presence of sulphisoxazole. Lancet. 1975 Apr 12;1(7911):824–827.
Journal cover image

Published In

Lancet

DOI

ISSN

0140-6736

Publication Date

April 12, 1975

Volume

1

Issue

7911

Start / End Page

824 / 827

Location

England

Related Subject Headings

  • Sulfisoxazole
  • Phagocytosis
  • Phagocytes
  • Male
  • Leukocytes
  • Infections
  • Infant
  • Humans
  • Granulomatous Disease, Chronic
  • General & Internal Medicine