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Serum IgD and IgE concentrations in immunodeficiency diseases.

Publication ,  Journal Article
Buckley, RH; Fiscus, SA
Published in: J Clin Invest
January 1975

Concentrations of IgD and IgE were measured in sera from 165 patients with well-defined immunodeficiency in an effort to find information possibly relevant to the roles of antibodies of these classes in host defense. Values for both immunoglobulins were generally quite low in patients who had marked deficiencies of all three major immunoglobulins, although occasional normal or high normal values for IgD were seen in hypogammaglobulinemic patients. Group mean IgD concentrations were also depressed in patients with Wiskott-Aldrich syndrome and in those with selective IgA deficiency; IgE concentrations were depressed in patients with X-linked immunodeficiency with hyper-IgM and in those with ataxia telangiectasia. IgD and IgE were both significantly elevated in patients with extreme hyperimmunoglobulinemia E and undue susceptibility to infection and in a patient with the Nezelof syndrome; none of these patients had histories suggestive of atopy. In addition, the mean IgE concentration was significantly elevated in patients with selective IgA deficiency, many of whom were atopic, and in those with the Wiskott-Aldrich syndrome. The highest IgD concentration (163 mg/100 ml) was found in serum from a boy with variable immunodeficiency who had a lifelong history of severe recurrent pharyngeal infections, primarily streptococcal in etiology. Recurrent staphylococcal infection was a feature common to many but not all patients with elevated serum IgE concentration. These data may prove useful in the future delineation of biologic roles for antibodies in these two immunoglobulin classes.

Duke Scholars

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

January 1975

Volume

55

Issue

1

Start / End Page

157 / 165

Location

United States

Related Subject Headings

  • Rabbits
  • Middle Aged
  • Infant
  • Immunology
  • Immunologic Deficiency Syndromes
  • Immunoglobulin M
  • Immunoglobulin E
  • Immunoglobulin D
  • Immunoglobulin A
  • Immunodiffusion
 

Citation

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Buckley, R. H., & Fiscus, S. A. (1975). Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest, 55(1), 157–165. https://doi.org/10.1172/JCI107906
Buckley, R. H., and S. A. Fiscus. “Serum IgD and IgE concentrations in immunodeficiency diseases.J Clin Invest 55, no. 1 (January 1975): 157–65. https://doi.org/10.1172/JCI107906.
Buckley RH, Fiscus SA. Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest. 1975 Jan;55(1):157–65.
Buckley, R. H., and S. A. Fiscus. “Serum IgD and IgE concentrations in immunodeficiency diseases.J Clin Invest, vol. 55, no. 1, Jan. 1975, pp. 157–65. Pubmed, doi:10.1172/JCI107906.
Buckley RH, Fiscus SA. Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest. 1975 Jan;55(1):157–165.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

January 1975

Volume

55

Issue

1

Start / End Page

157 / 165

Location

United States

Related Subject Headings

  • Rabbits
  • Middle Aged
  • Infant
  • Immunology
  • Immunologic Deficiency Syndromes
  • Immunoglobulin M
  • Immunoglobulin E
  • Immunoglobulin D
  • Immunoglobulin A
  • Immunodiffusion