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Depression of cell-mediated immunity in atopic eczema.

Publication ,  Journal Article
McGeady, SJ; Buckley, RH
Published in: J Allergy Clin Immunol
November 1975

Prompted by recent observations that the thymus exerts an important regulatory influence over IgE antibody production in lower species, we conducted studies of immune function in 21 patients with atopic eczema to seek evidence for a similar relation in man. Skin tests for delayed hypersensitivity to Candida albicans and streptokinase-streptodornase (SK-SD) revealed a striking degree of anergy that correlated with the severity of the eczema. A correlation was also noted between the extent of the dermatitis and the magnitude of the serum IgE concentration. Other immunologic abnormalities did not appear related to the severity of eczema put pertained to the group as a whole. These included significantly (p = less than 0.0001) lower mean percentages of spontaneous sheep erythrocyte (E) or T cell rosettes and of rosettes with neuraminidase-treated sheep erythrocyte (En) rosettes, and significantly lower in vitro lymphocyte responsiveness of the mitogens concanavalin A (p = 0.0013) and poleweek mitogen (p = 0.0002) and to Candida antigen (p = 0.0017) than in normal subjects. Responses to phytohemagglutinin and tetanus toxoid were also depressed but differences were not statistically significant. An increased percentage (p = 0.0324) of peripheral blood B lymphocytes bearing the complement receptor was noted, but, except for a slight increase in lymphocytes bearing IgD, percentages of lymphocytes bearing other immunoglobulins (including IgE) were not elevated.

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Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

November 1975

Volume

56

Issue

5

Start / End Page

393 / 406

Location

United States

Related Subject Headings

  • Streptodornase and Streptokinase
  • Skin Tests
  • Receptors, Antigen, B-Cell
  • Male
  • Lymphocyte Activation
  • Infant
  • Immunoglobulin M
  • Immunoglobulin G
  • Immunoglobulin E
  • Immunoglobulin D
 

Citation

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McGeady, S. J., & Buckley, R. H. (1975). Depression of cell-mediated immunity in atopic eczema. J Allergy Clin Immunol, 56(5), 393–406. https://doi.org/10.1016/0091-6749(75)90133-5
McGeady, S. J., and R. H. Buckley. “Depression of cell-mediated immunity in atopic eczema.J Allergy Clin Immunol 56, no. 5 (November 1975): 393–406. https://doi.org/10.1016/0091-6749(75)90133-5.
McGeady SJ, Buckley RH. Depression of cell-mediated immunity in atopic eczema. J Allergy Clin Immunol. 1975 Nov;56(5):393–406.
McGeady, S. J., and R. H. Buckley. “Depression of cell-mediated immunity in atopic eczema.J Allergy Clin Immunol, vol. 56, no. 5, Nov. 1975, pp. 393–406. Pubmed, doi:10.1016/0091-6749(75)90133-5.
McGeady SJ, Buckley RH. Depression of cell-mediated immunity in atopic eczema. J Allergy Clin Immunol. 1975 Nov;56(5):393–406.
Journal cover image

Published In

J Allergy Clin Immunol

DOI

ISSN

0091-6749

Publication Date

November 1975

Volume

56

Issue

5

Start / End Page

393 / 406

Location

United States

Related Subject Headings

  • Streptodornase and Streptokinase
  • Skin Tests
  • Receptors, Antigen, B-Cell
  • Male
  • Lymphocyte Activation
  • Infant
  • Immunoglobulin M
  • Immunoglobulin G
  • Immunoglobulin E
  • Immunoglobulin D