Skip to main content
Journal cover image

Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.

Publication ,  Journal Article
Oakey, RJ; Caron, MG; Lefkowitz, RJ; Seldin, MF
Published in: Genomics
June 1991

Five sequence-related genes encoding four adrenergic receptors and a serotonin receptor were localized to specific regions of four mouse chromosomes with respect to 11 other genetic markers. Linkage was established by the analysis of the haplotypes of 114 interspecific backcross mice. Adra2r (alpha 2-C10) and Adrb1r (beta 1) receptors mapped to the distal region of mouse chromosome 19. These genes were separated by 2.6 +/- 1.5 cM in a segment of mouse chromosome 19 that has a similar organization of these genes on the long arm of human chromosome 10. The Adra1r (alpha 1B), Adrb2r (beta 2), and Htra1 (5HT1A) genes mapped to proximal mouse chromosome 11, proximal mouse chromosome 18, and distal mouse chromosome 13, respectively. The organization of genes linked to these loci on regions of the three mouse chromosomes is consistent with the organization of homologous human genes on human chromosome 5. These findings further define the relationship of linkage groups conserved during the evolution of the mouse and human genomes. We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

June 1991

Volume

10

Issue

2

Start / End Page

338 / 344

Location

United States

Related Subject Headings

  • Receptors, Serotonin
  • Receptors, Adrenergic
  • Polymorphism, Restriction Fragment Length
  • Mice, Inbred C3H
  • Mice
  • Humans
  • Haplotypes
  • Genetics & Heredity
  • DNA Probes
  • Crosses, Genetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

June 1991

Volume

10

Issue

2

Start / End Page

338 / 344

Location

United States

Related Subject Headings

  • Receptors, Serotonin
  • Receptors, Adrenergic
  • Polymorphism, Restriction Fragment Length
  • Mice, Inbred C3H
  • Mice
  • Humans
  • Haplotypes
  • Genetics & Heredity
  • DNA Probes
  • Crosses, Genetic