Skip to main content

The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers.

Publication ,  Journal Article
Berry, JJ; Baker, JA; Pieper, KS; Hanson, MW; Hoffman, JM; Coleman, RE
Published in: J Nucl Med
August 1991

Cardiac PET imaging using 13N-ammonia and 18FDG was performed on 17 normal volunteers in the glucose-loaded and fasted states. PET images (glucose-loaded and fasted) were subjected to qualitative visual analysis using the descriptors: image quality, FDG blood-pool activity, ammonia lung field activity, and clinical interpretability. Glucose-loaded studies had better image quality, diminished FDG blood-pool activity, and were more often clinically interpretable compared to fasted studies. Dietary state did not affect 13N-ammonia study parameters. Using a semi-quantitative region of interest method, 18FDG myocardial activity was homogeneous and significantly affected by dietary state (2.48 +/- 1.0 fold increase in myocardial-to-blood pool ratio in glucose-loaded versus fasted states). Serum glucose, insulin, and free-fatty acid concentrations responded physiologically to glucose loading and fasting but showed no correlation with myocardial 18FDG uptake. PET imaging using 13N-ammonia and 18FDG appears optimal in the glucose-loaded state.

Duke Scholars

Published In

J Nucl Med

ISSN

0161-5505

Publication Date

August 1991

Volume

32

Issue

8

Start / End Page

1518 / 1525

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Nuclear Medicine & Medical Imaging
  • Nitrogen Radioisotopes
  • Myocardium
  • Middle Aged
  • Male
  • Insulin
  • Image Processing, Computer-Assisted
  • Humans
  • Heart
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Berry, J. J., Baker, J. A., Pieper, K. S., Hanson, M. W., Hoffman, J. M., & Coleman, R. E. (1991). The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers. J Nucl Med, 32(8), 1518–1525.
Berry, J. J., J. A. Baker, K. S. Pieper, M. W. Hanson, J. M. Hoffman, and R. E. Coleman. “The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers.J Nucl Med 32, no. 8 (August 1991): 1518–25.
Berry JJ, Baker JA, Pieper KS, Hanson MW, Hoffman JM, Coleman RE. The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers. J Nucl Med. 1991 Aug;32(8):1518–25.
Berry JJ, Baker JA, Pieper KS, Hanson MW, Hoffman JM, Coleman RE. The effect of metabolic milieu on cardiac PET imaging using fluorine-18-deoxyglucose and nitrogen-13-ammonia in normal volunteers. J Nucl Med. 1991 Aug;32(8):1518–1525.

Published In

J Nucl Med

ISSN

0161-5505

Publication Date

August 1991

Volume

32

Issue

8

Start / End Page

1518 / 1525

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Nuclear Medicine & Medical Imaging
  • Nitrogen Radioisotopes
  • Myocardium
  • Middle Aged
  • Male
  • Insulin
  • Image Processing, Computer-Assisted
  • Humans
  • Heart