Evidence for loss of heterozygosity of 5q in sporadic haemangiomas: are somatic mutations involved in haemangioma formation?
BACKGROUND/AIMS: Haemangiomas are common benign tumours of infancy that consist of rapidly proliferating endothelial cells. A locus for an autosomal dominant predisposition to haemangioma has been identified recently on chromosome 5q. This study aimed to investigate loss of heterozygosity on chromosomes 5 and 9 in haemangiomas. METHODS: Sporadic proliferative phase haemangiomas were microdissected. Polymerase chain reaction amplification and analysis of microsatellite markers on chromosomes 5 and 9 was carried out. RESULTS: There was a significant loss of heterozygosity for markers on chromosome 5q in haemangioma tissue, when compared with either markers from chromosome 5p (p < 0.05) or markers from chromosome 9 (p < 0.05). CONCLUSIONS: These results suggest that haemangioma formation might be associated with somatic mutational events, and provides evidence that a locus on 5q is involved in the formation of sporadic haemangiomas.
Duke Scholars
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Related Subject Headings
- Pathology
- Microsatellite Repeats
- Male
- Loss of Heterozygosity
- Infant
- Humans
- Hemangioma
- Female
- Chromosomes, Human, Pair 9
- Chromosomes, Human, Pair 5
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Pathology
- Microsatellite Repeats
- Male
- Loss of Heterozygosity
- Infant
- Humans
- Hemangioma
- Female
- Chromosomes, Human, Pair 9
- Chromosomes, Human, Pair 5