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Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation.

Publication ,  Journal Article
Evans, AJ; Iwai, F; Grist, TA; Sostman, HD; Hedlund, LW; Spritzer, CE; Negro-Vilar, R; Beam, CA; Pelc, NJ
Published in: Invest Radiol
February 1993

RATIONALE AND OBJECTIVES: One promising approach to flow quantification uses the velocity-dependent phase change of moving protons. A velocity-encoding phase subtraction technique was used to measure the velocity and flow rate of fluid flow in a phantom and blood flow in volunteers. METHODS: In a model, the authors measured constant flow velocities from 0.1 to 270.0 cm/second with an accuracy (95% confidence intervals) of +/- 12.5 cm/second. There was a linear relationship between the magnetic resonance imaging (MRI) measurement and the actual value (r2 = .99; P = .0001). RESULTS: Measuring mean pulsatile flow from 125 to 1,900 mL/minute, the accuracy of the MRI pulsatile flow measurements (95% confidence intervals) was +/- 70 mL/minute. There was a linear relationship between the MRI pulsatile flow measurement and the actual value (r2 = .99; P = .0001). In 10 normal volunteers, the authors tested the technique in vivo, quantitating flow rates in the pulmonary artery and the aorta. The average difference between the two measurements was 5%. In vivo carotid flow waveforms obtained with MRI agreed well with the shape of corresponding ultrasound Doppler waveforms. CONCLUSIONS: Velocity-encoding phase subtraction MRI bears potential clinical use for the evaluation of blood flow. Potential applications would be in the determination of arterial blood flow to parenchymal organs, the detection and quantification of intra- and extra-cardiac shunts, and the rapid determination of cardiac output and stroke volume.

Duke Scholars

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

February 1993

Volume

28

Issue

2

Start / End Page

109 / 115

Location

United States

Related Subject Headings

  • Ultrasonography
  • Subtraction Technique
  • Pulsatile Flow
  • Pulmonary Artery
  • Nuclear Medicine & Medical Imaging
  • Models, Structural
  • Magnetic Resonance Imaging
  • In Vitro Techniques
  • Humans
  • Carotid Arteries
 

Citation

APA
Chicago
ICMJE
MLA
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Evans, A. J., Iwai, F., Grist, T. A., Sostman, H. D., Hedlund, L. W., Spritzer, C. E., … Pelc, N. J. (1993). Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation. Invest Radiol, 28(2), 109–115. https://doi.org/10.1097/00004424-199302000-00004
Evans, A. J., F. Iwai, T. A. Grist, H. D. Sostman, L. W. Hedlund, C. E. Spritzer, R. Negro-Vilar, C. A. Beam, and N. J. Pelc. “Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation.Invest Radiol 28, no. 2 (February 1993): 109–15. https://doi.org/10.1097/00004424-199302000-00004.
Evans AJ, Iwai F, Grist TA, Sostman HD, Hedlund LW, Spritzer CE, et al. Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation. Invest Radiol. 1993 Feb;28(2):109–15.
Evans, A. J., et al. “Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation.Invest Radiol, vol. 28, no. 2, Feb. 1993, pp. 109–15. Pubmed, doi:10.1097/00004424-199302000-00004.
Evans AJ, Iwai F, Grist TA, Sostman HD, Hedlund LW, Spritzer CE, Negro-Vilar R, Beam CA, Pelc NJ. Magnetic resonance imaging of blood flow with a phase subtraction technique. In vitro and in vivo validation. Invest Radiol. 1993 Feb;28(2):109–115.

Published In

Invest Radiol

DOI

ISSN

0020-9996

Publication Date

February 1993

Volume

28

Issue

2

Start / End Page

109 / 115

Location

United States

Related Subject Headings

  • Ultrasonography
  • Subtraction Technique
  • Pulsatile Flow
  • Pulmonary Artery
  • Nuclear Medicine & Medical Imaging
  • Models, Structural
  • Magnetic Resonance Imaging
  • In Vitro Techniques
  • Humans
  • Carotid Arteries