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Prospective investigation of positron emission tomography in lung nodules.

Publication ,  Journal Article
Lowe, VJ; Fletcher, JW; Gobar, L; Lawson, M; Kirchner, P; Valk, P; Karis, J; Hubner, K; Delbeke, D; Heiberg, EV; Patz, EF; Coleman, RE
Published in: J Clin Oncol
March 1998

PURPOSE: Solitary pulmonary nodules (SPNs) are commonly identified by chest radiographs and computed tomography (CT). Biopsies are often performed to evaluate the nodules further. An accurate, noninvasive diagnostic test could avoid the morbidity and costs of invasive tissue sampling. We evaluated the ability of fluorine-18 deoxyglucose positron emission tomography (FDG-PET) to discriminate between benign and malignant pulmonary nodules in a prospective, multicenter trial. METHODS: Eighty-nine patients who had newly identified indeterminate SPNs on chest radiographs and CT were evaluated with FDG-PET. PET data were analyzed semiquantitatively by calculating standardized uptake values (SUVs) as an index of FDG accumulation and also by a visual scoring method. PET results were compared with pathology results. RESULTS: Sixty SPNs were malignant and 29 were benign. Using SUV data, PET had an overall sensitivity and specificity for detection of malignant nodules of 92% and 90%. Visual analysis provided a slightly higher, but not statistically significant, sensitivity of 98% and lower specificity of 69%. For SPNs < or = 1.5 cm (34 of 89), the sensitivity and specificity of SUV and visual analysis were 80% and 95% and 100% and 74%, respectively. CONCLUSION: FDG-PET can accurately characterize indeterminate SPNs. PET imaging provides a noninvasive method to evaluate indeterminate SPNs, which can reduce the need for invasive tissue biopsy.

Duke Scholars

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Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

March 1998

Volume

16

Issue

3

Start / End Page

1075 / 1084

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Solitary Pulmonary Nodule
  • Sensitivity and Specificity
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Fluorodeoxyglucose F18
 

Citation

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Lowe, V. J., Fletcher, J. W., Gobar, L., Lawson, M., Kirchner, P., Valk, P., … Coleman, R. E. (1998). Prospective investigation of positron emission tomography in lung nodules. J Clin Oncol, 16(3), 1075–1084. https://doi.org/10.1200/JCO.1998.16.3.1075
Lowe, V. J., J. W. Fletcher, L. Gobar, M. Lawson, P. Kirchner, P. Valk, J. Karis, et al. “Prospective investigation of positron emission tomography in lung nodules.J Clin Oncol 16, no. 3 (March 1998): 1075–84. https://doi.org/10.1200/JCO.1998.16.3.1075.
Lowe VJ, Fletcher JW, Gobar L, Lawson M, Kirchner P, Valk P, et al. Prospective investigation of positron emission tomography in lung nodules. J Clin Oncol. 1998 Mar;16(3):1075–84.
Lowe, V. J., et al. “Prospective investigation of positron emission tomography in lung nodules.J Clin Oncol, vol. 16, no. 3, Mar. 1998, pp. 1075–84. Pubmed, doi:10.1200/JCO.1998.16.3.1075.
Lowe VJ, Fletcher JW, Gobar L, Lawson M, Kirchner P, Valk P, Karis J, Hubner K, Delbeke D, Heiberg EV, Patz EF, Coleman RE. Prospective investigation of positron emission tomography in lung nodules. J Clin Oncol. 1998 Mar;16(3):1075–1084.

Published In

J Clin Oncol

DOI

ISSN

0732-183X

Publication Date

March 1998

Volume

16

Issue

3

Start / End Page

1075 / 1084

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Solitary Pulmonary Nodule
  • Sensitivity and Specificity
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Fluorodeoxyglucose F18