Skip to main content

Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.

Publication ,  Journal Article
Fukudo, S; Virnelli, S; Kuhn, CM; Cochrane, C; Feinglos, MN; Surwit, RS
Published in: Diabetes
November 1989

Plasma glucose and insulin responses to a muscarinic agonist (bethanechol chloride) and a muscarinic antagonist (atropine) were evaluated in obese C57BL/6J ob/ob mice and in lean C57BL/6J + /? mice. In lean +/? mice, plasma glucose decreased in response to 1 and 2 micrograms/g bethanechol chloride, whereas insulin increased significantly. In ob/ob mice, insulin increased remarkably in response to bethanechol administration (saline, 632 +/- 80 microU/ml; 2 micrograms/g bethanechol chloride, 1794 +/- 97 microU/ml; n = 10), but surprisingly, plasma glucose also rose significantly (saline, 230 +/- 14 mg/dl; 2 micrograms/g bethanechol chloride, 363 +/- 18 mg/dl, n = 10). This exaggerated hyperglycemia in ob/ob mice was not associated with significant changes in plasma glucagon. Furthermore, administration of propranolol hydrochloride did not diminish bethanechol chloride-induced hyperglycemia in ob/ob mice. Administration of atropine (2.5, 5, and 10 mg/kg body wt) induced a significant decrease in plasma insulin without changes in plasma glucose in ob/ob mice, whereas neither plasma insulin nor plasma glucose changed in lean mice. Finally, conversion of [14C]alanine to glucose was increased in ob/ob mice after bethanechol chloride administration, indicating that muscarinic stimulation increases gluconeogenesis in an animal model of type II (non-insulin-dependent) diabetes.

Duke Scholars

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

November 1989

Volume

38

Issue

11

Start / End Page

1433 / 1438

Location

United States

Related Subject Headings

  • Propranolol
  • Mice, Obese
  • Mice
  • Liver
  • Insulin
  • Homeostasis
  • Glucose
  • Glucagon
  • Endocrinology & Metabolism
  • Dose-Response Relationship, Drug
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fukudo, S., Virnelli, S., Kuhn, C. M., Cochrane, C., Feinglos, M. N., & Surwit, R. S. (1989). Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice. Diabetes, 38(11), 1433–1438. https://doi.org/10.2337/diab.38.11.1433
Fukudo, S., S. Virnelli, C. M. Kuhn, C. Cochrane, M. N. Feinglos, and R. S. Surwit. “Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.Diabetes 38, no. 11 (November 1989): 1433–38. https://doi.org/10.2337/diab.38.11.1433.
Fukudo S, Virnelli S, Kuhn CM, Cochrane C, Feinglos MN, Surwit RS. Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice. Diabetes. 1989 Nov;38(11):1433–8.
Fukudo, S., et al. “Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice.Diabetes, vol. 38, no. 11, Nov. 1989, pp. 1433–38. Pubmed, doi:10.2337/diab.38.11.1433.
Fukudo S, Virnelli S, Kuhn CM, Cochrane C, Feinglos MN, Surwit RS. Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice. Diabetes. 1989 Nov;38(11):1433–1438.

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

November 1989

Volume

38

Issue

11

Start / End Page

1433 / 1438

Location

United States

Related Subject Headings

  • Propranolol
  • Mice, Obese
  • Mice
  • Liver
  • Insulin
  • Homeostasis
  • Glucose
  • Glucagon
  • Endocrinology & Metabolism
  • Dose-Response Relationship, Drug